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The expression profile of the toll-like receptor (TLR) family in scleroderma (SSc) dermal fibroblasts. TLR5 and TLR10 expression is increased in SSc fibroblasts. TLR5 itself may have suppressive effects on collagen expression, and its overexpression in SSc fibroblasts may be the negative feedback against tissue fibrosis. Clinical and Experimental Rheumatology, 14 June 2014. (Also see: Skin Fibrosis)

Do Not Take Daily Aspirin If You Haven't Had a Heart Attack, Says FDA. Taking a daily aspirin is not necessary for people with no history of heart problems, the U.S. Food and Drug Administration (FDA) says. Time Healthland, 05/06/2014.

Perioperative management of antiphospholipid antibody(aPL)-positive patients. There are limited data on which to base recommendations and periods without anticoagulation should be kept to an absolute minimum for patients with a history of thrombosis. PubMed, Curr Rheumatol Rep. 2014 Jul;16(7):426. (Also see: Antiphospholid Syndrome)

Solitary organizing pneumonia (SOP) in systemic sclerosis (SSc) mimicking lung adenocarcinoma. SOP is often misdiagnosed and removed surgically as it is rare and difficult to distinguish from lung carcinoma. SOP should be considered when a solitary nodular lung lesion is noted in a patient with SSc. PubMed, Arthritis Rheumatol, 2014 Apr 22. (Also see: Lung Involvement: Pneumonia and Cancer and Scleroderma)

UCLA's 'Laughter Guy' dissects features of counterfeit chortling. Phoney laughter, unlike the real thing is unique to humans, study suggests. UCLA Newsroom, 05/01/2014.

The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease. In multi-system autoimmune disease, prior cyclophosphamide exposure and glucocorticoid therapy but not cumulative rituximab dose was associated with an increased incidence of hypogammaglobulinaemia and repeat dose rituximab therapy appears safe with judicious monitoring. PubMed, BMC Musculoskelet Disord, 2014 May 25;15(1):178. (Also see: Mainstream Treatments: Biologics)

Echocardiographic follow-up of patients with systemic sclerosis (SSc) by 2D speckle tracking echocardiography (STE) of the left ventricle (LV). STE might be a sensititive and valuable method to detect early LV systolic impairment in patients with SSc and preserved LV ejection fraction during two years and prospective evaluations are needed for prognostic implications of these changes. PubMed, Cardiovasc Ultrasound, 2014 Mar 29;12(1):13. (Also see: Scleroderma Heart Involvement)

WHO Declares Health Emergency on Polio. The recent spread of the polio virus is a public health emergency of international concern, the World Health Organization said. Time Healthland, 05/05/2014.

Rituximab therapy in patients with refractory dermatomyositis (DM) or polymyositis (PM): differential effects in a real-life population. Objective improvement was seen in the majority of patients with regard to creatine phosphokinase (CPK) and lung function tests, and glucocorticoids could be reduced. PubMed, Rheumatology (Oxford). 2014 Apr 4. (Also see: Dermatomyositis and Polymyositis Treatments)

Improved transplant-free survival in patients with systemic sclerosis-associated pulmonary hypertension and interstitial lung disease (SSc-PH-ILD). Survival of patients with SSc-PH-ILD has modestly improved, and may partly be due to aggressive PAH-targeted therapy. PubMed, Arthritis Rheumatol, 2014 Apr 11. (Also see: Lung Transplant for Pulmonary Fibrosis)

Young blood rejuvenates brains and muscles of old mice. If three discoveries in mice reported on Sunday are applicable to people, making old brains and old muscles perform like young ones may require simply a blood transfusion. Reuters,05/0/2014.

Genome-wide association studies in Sjögren's syndrome (SS): What do the genes tell us about disease pathogenesis? Genetic findings are discussed with particular attention paid to the genes identified, the strength of associations, and how the SS-associated genes compare to what has been discovered previously in systemic lupus erythematosus (SLE). PubMed, Autoimmun Rev, 2014 Jul;13(7):756-761. (Also see: Sjogren's Syndrome and Causes of Lupus: Genetics)



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