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The effects of hormone replacement therapy (HRT) on autoimmune disease: rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Prospective trials suggests that there may be a small increased risk of mild/moderate flares in women with SLE taking hormone replacement therapy (HRT), but the risk of major flare does not appear to be increased. In RA, HRT does not appear to be associated with an increased risk of disease flare and may actually improve disease activity. In all individuals with autoimmune disease, the risk of venous thrombosis associated with oral HRT is an important factor that should also be considered. (InformaWorld) C.R. Holroyd. Climacteric. October 2009. (Also see: Autoimmunity)

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