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Hydroxychloroquine (HCQ) improves dry eye symptoms of patients with primary Sjogren’s syndrome (pSS)

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#1 GocartMoz


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Posted 15 April 2010 - 11:04 AM

Hydroxychloroquine (HCQ) improves dry eye symptoms of patients with primary Sjogren’s syndrome (pSS). The results of this study suggest that HCQ may alleviate symptoms and signs of dry eye in pSS and decreases tear fluid B-cell activating factor (BAFF) levels. Sule Yavuz Rheumatology International. 23 March 2010 (Also see: Treatments for Dry Eyesand Antimalarials)

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#2 Margaret


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Posted 15 April 2010 - 11:47 AM

Hi David ,

This was interesting to read since Gareth seems to be developing SS and he's been on Plaquenil for almost 3 years. In Jan, the dentist commented on how dry his mouth was and, in Feb., he had to go to the eye doctor (because he's on the Plaquenil!!!) and he did the Schirmer's (sp) test and he flunked that. His blood work was negative for SS, but it makes me wonder if it wouldn't be positive if he wasn't on Plaquenil. Sounds like a circle going around!!!

Take care, Everyone.

#3 Sweet


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Posted 16 April 2010 - 10:23 AM

My Doctor was just telling me about this. I've been on Plaquenil for 10 years, but just recently had to go on Evoxac as well for the Sjogrens.
Warm and gentle hugs,

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International Scleroderma Network (ISN)

#4 Guest_Soaring Eagle_*

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Posted 17 April 2010 - 09:51 AM

I have been on plaquenil for as long as I can remember. In January, 2009 I started taking Evoxac after being diagnosed with secondary Sjogren's the previous October. My GI doctor told me that Evoxac is actually an anti-cholinergic (I think I'm using the right term; I should have found my notes and double-checked before I started writing) and would stimulate contractions of the stomach. Therefore, he suggested we try stopping the domperidone which I had used for about 3 years. I have not missed it enough to justify the expense and the dread of "having to take one more medicine." I get a little more nauseated than I did when I was on the domperidone, but it's manageable. I do continue to take Zofran 3 times a day and use phenergan on occasion for break-through nausea.

Even with the Evoxac I have to use eye drops a couple of times a night. I also use them when I wake up, but usually only have to use them 1-2 times a day at the most. It's interesting to me that my eyes get drier at night than they do during the day.

#5 Deb1million


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Posted 21 April 2010 - 09:46 AM

I've been on Plaquenil for almost 2 years, and in that time have developed Sjogrens. I also have to attend the eye clinic regularly for high intra-occular pressure (glaucoma) in one eye only.
My eyes are much worse in the night, and it's painful to even try and move my eyes until Ive used the gel. Its such a relief when the eye gel drops in!