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X chromosome monosomy in primary and overlapping autoimmune diseases


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#1 Jeannie McClelland

Jeannie McClelland

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Posted 19 April 2010 - 06:01 AM

X chromosome monosomy in primary and overlapping autoimmune diseases. Female predominance is a common characteristic for autoimmune diseases attributed to the combined effect of hormonal influence and genetic factors. Since X chromosome has immunologically important genes, the age related X chromosome loss could contribute to the development of autoimmunity. X chromosome monosomy (XCM) has been associated with primary biliary cirrhosis (PBC) and systemic sclerosis. Y Svyryd. (PubMed) Autoimmun Rev. 2010 Mar 15. (Also see: Chromosomes)

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