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Male-only Systemic Lupus (SLE)


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#1 GocartMoz

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Posted 27 May 2010 - 10:14 AM

Male-only Systemic Lupus (SLE). Because women in the all-male families had positive antinuclear antibodies, and men are more likely to have children with SLE, these data suggest genetic susceptibility factors that act only in men. R. Aggarwal. Journal of Rheumatology. May 15, 2010. (Also see: Lupus and Genetics)

This item was posted in the ISN Newsroom. Check the Newsroom every day for the latest scleroderma medical and support information.

#2 Margaret

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Posted 27 May 2010 - 02:33 PM

Hi Dave ,

I am always interested in articles about genetics and diseases. Three out of my four brothers have Hemochromatosis. All 3 with the disease have only girls. The one brother without it has a son. It's interesting that out of 7 kids, 12 grandkids, there is only one heir to carry on Dad's name, all because males with H don't have sons. We have come so far with genetics, diseases, etc, but have so much to learn. Now if I can only figure out where Gareth got the Sclero/UCDT!!!

Take care, Everyone.

Margaret

#3 Sheryl

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Posted 28 May 2010 - 01:21 AM

Margaret, do any of your sisters have sons? Do any of them have any autoimmune diseases at this time? Your one brother who has a son is he is perfect health? All these girls in the family do they have any symptoms of autoimmune disease? Many may still be quite young and one never knows sometime until years down the road. As you write over the years we will learn much from each other and our many different family relatives who have differing symptoms. One of my nephews was just diagnosis with Addison's disease. Adrenal problems are causing problems with his young body. I guess somewhere in our gene factory things are just getting distorted and there is no stopping what will develop years and generations down the road. Medically speaking it could be a nightmare. Though modern science in the future who knows what medical discoveries will take place.
Strength and Warmth,
Sheryl

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#4 CraigR

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Posted 28 May 2010 - 01:47 PM

This is an interesting bit of information.

I have heard of studies suggesting a similar effect with scleroderma. I have sclero and so did my father (though none of the females in the family have any sort of autoimmiune disease). Thus I'm inclined to believe something genetic is going on...

Craig

#5 Margaret

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Posted 29 May 2010 - 08:39 AM

Sheryl ,

I have 2 sisters --- I have 2 boys, one sis has 1 B/1G, and my other sis has 2 B's/1G. But, our husbands decide the sex!!! All of us girls are relatively healthy with no autoimmune issues....one has no problems, I have wicked GERD, and one has kidney stones alot. My Dad did have RA but that's the only autoimmune issues I know of and no others in our family have any ---just Gareth. I find genetics very interesting!!! In hindsight, although Dad never had skin issues, he did have numerous pulmonary (breathing), gastric (GERD), intestinal 'issues', fat/swollen fingers, etc. He died 14 years ago of an AAA and, back then, I don't think anyone would think of Sclero.

Take care, Everyone,
Margaret

#6 judyt

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Posted 30 May 2010 - 09:26 PM

Hi Everybody,
Just to put the cat amongst the pigeons, my husband's best friend has Hemochromotosis, and his family consists of one son and one daughter. The son has two sons, and the daughter has two daughters and one son. That particular boy is unfortunate enough to have inherited Muscular Distrophy, which they have said comes from his mother, although no others in the family have any history of carrying that gene as far as I have been told. I find genetics absolutely fascinating and still remember my high school studies of Gregor Mendel and his Sweet Peas!!!

Both of our children are adopted and so are not biologically related to either of us. Both of them happen to know their birth parents, and that knowledge has put paid to the old story of taking a child for 7 years and changing the course of their life (or whatever that story was). Even though our daughter didn't meet her mother until 14 and her father until 16 years of age, she talks and laughs and thinks like her mother and I couldn't believe what I was hearing the first time I spoke to her mother on the phone.

I had better stop rambling or somebody will edit me out for getting off the subject.

Warm hugs from downunder again today.

Judy T

#7 Margaret

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Posted 31 May 2010 - 01:46 PM

Hi Judy ,

That is quite interesting since my brother was told by a doctor that males (with H) do not have sons. Glad your friend's son seems to be OK. Just goes to show you that you shouldn't always believe everything you're told!!!

Take care, Everyone.
Margaret