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Clinical and Molecular Evidence for Association of Systemic Lupus Erythematosus (SLE) with parvovirus B19


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#1 Jeannie McClelland

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Posted 02 August 2010 - 04:17 PM

Clinical and Molecular Evidence for Association of Systemic Lupus Erythematosus (SLE) with parvovirus B19. Parvovirus B19, the cause of Fifth disease in childhood, and possible trigger in the spectrum of autoimmune diseases in adults, has emerged as one of the central viral candidates within the last few years. M. Pavlovic. Lupus June 2010 vol. 19 no. 7 783-792. (Also see: Causes of Lupus)


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Jeannie McClelland
(Retired) ISN Director of Support Services
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International Scleroderma Network

#2 Jeannie McClelland

Jeannie McClelland

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Posted 02 August 2010 - 04:30 PM

Hi All,

I wanted to do a little more reading on this subject. Probably like a lot of people, I associated parvovirus with dogs (where it can be quickly fatal) and wondered what the connection to human parvoviruses is. Specifically, I wondered if the virus could pass back and forth between animals and humans. According to the CDC info page on Parvovirus B:19, the answer is no.

I also wondered about Fifth Disease. My two oldest kids had it when they were around 8-10 and the pediatrician was quite excited because the rash was picture-perfect classic. The CDC info page I mentioned above says that Fifth Disease is very common, much more so than I would have guessed. (As far as the autoimmune connection goes, only the oldest of my two who had it has any kind of an autoimmune problem and he has sarcoidosis.) I wonder how many of us may have had Fifth Disease and not known it. If I read the CDC article correctly, a positive antibody test is only likely in the case of a recent infection. It could be an interesting line of investigation.

Best wishes,
Jeannie McClelland
(Retired) ISN Director of Support Services
(Retired) ISN Sclero Forums Manager
(Retired) ISN Blog Manager
(Retired) ISN Assistant News Guide
(Retired) ISN Artist
International Scleroderma Network