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Biomarker for Diffuse Scleroderma skin has been discovered!


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My bloodwork came back today...


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#1 mopsygirl

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Posted 05 January 2011 - 02:24 PM

And was ANA positive. I guess this just solidifies what we already knew based on my symptoms. I am feeling optimistic about beginning the MTX, and hoping that we can get it into remission soon.

#2 Joelf

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Posted 05 January 2011 - 07:31 PM

Hi Kelsie

I'm pleased to hear that you've had the results of your blood tests. :)

I can empathise with you as I felt very much more relieved and positive when I actually found out what I had wrong with me and I felt I had a legitimate reason for having felt so ill.

I have tested positive for the AntiPM/Scl and IgG antibodies and my blood tests showed antibodies with the speckled nucleolar pattern. I have to admit that it gave me a lot of pleasure googleing details and pictures of antibodies such as mine when I was first diagnosed ( I'm probably a bit sad though and need to get out more!! :rolleyes: :lol: ) as I was very keen to find out as much as I could about Scleroderma. I've found that knowledge of this bizarre disease helps me to come to terms with it! ;)

I'm glad you're feeling positive about taking Methotrexate; I'm on Azathioprine and Prednisolone and as soon as I started on my medication I felt much better, so I'm hoping you will have the same result! :VeryHappy:

Do keep us posted!

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#3 Amanda Thorpe

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Posted 06 January 2011 - 04:40 AM

Hello Kelsie

I hope you find the methotrexate helpful, I've been on it for about 2 years now I think. It can cause side effects like nausea and fatigue but they can wear off so don't be discouraged if you have any initially. I started methotrexate having developed unbearable side effects on mycophenolate and so far so good!

Take car nd keep posting.
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#4 debonair susie

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Posted 06 January 2011 - 06:52 AM

Hi mopsy,

I'm glad you feel relieved to have an answer to what you already felt.
I, too, hope the MTX works well for you!

Sending Very Soft :emoticon-hug: s your way...
Special Hugs,

Susie Kraft
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#5 mopsygirl

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Posted 07 January 2011 - 07:51 AM

Thanks for all of the support :)

Is there a reason why some people have bloodwork that comes back positive and some people's bloodwork comes back negative?

#6 Joelf

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Posted 07 January 2011 - 09:06 AM

Hi Kelsie

It does seem to be a rather bizarre situation that people who have many of the recognisable symptoms and to all intents and purposes have Scleroderma, also have their blood tests come back negative. I know this applies to quite a few of our members.

I'm no doctor, but the only thing I can think is that this is another peculiar phenomenon of this very complex disease. :unsure:

Jo Frowde
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#7 Sweet

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Posted 07 January 2011 - 01:33 PM

Sounds like good news! I'm glad you're feeling good about this! :happy-day:
Warm and gentle hugs,

Pamela
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#8 Robyn Sims

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Posted 07 January 2011 - 11:44 PM

Hi Kelsie,

Yes, finally getting a name for your symptoms, even the name scleroderma, does provide some relief. It also gives you validation.

I have known some people who have all the symptoms but no positive on the blood test. Often they are told it's a connective tissue disorder.

I also hope the methotrexate is the right drug for you. Keep us posted and we'll be thinking of you.

Robyn