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Lung tissues in systemic sclerosis (SSc) have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension


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#1 Jeannie McClelland

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Posted 27 January 2011 - 10:50 PM

Lung tissues in systemic sclerosis (SSc) have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension Using microarray analysis on carefully phenotyped SSc and comparator lung tissues, we demonstrated distinct molecular profiles in tissues and fibroblasts of patients with SSc-associated lung disease compared to idiopathic forms of lung disease. Unique molecular signatures were generated that are disease- (SSc) and phenotype- (PF vs PAH) specific. Eileen Hsu (PubMed) Arthritis and Rheumatism, Nov. 19, 2010. (Also see: Genetics and Pulmonary Involvement)

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#2 Joelf

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Posted 28 January 2011 - 11:43 AM

Thanks for posting this, Jeannie.

I found it very interesting as I remember being very impressed when I first saw my consultant at The Royal Brompton Hospital. They were able to tell from the pattern of the 'ground glass' on my lungs that it was a fibrosing organising pneumonia caused by Scleroderma and not Idiopathic Pulmonary Fibrosis which was what I had convinced myself I was suffering from (having foolishly googled 'Pulmonary Fibrosis' and scared myself witless!! :rolleyes: )

My consultant was able to look me squarely in the eye and assure me I didn't have IPF....what a relief!! :emoticons-yes:

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