Jump to content

Do you want up to date information about Scleroderma? Check out our Medical pages at www.sclero.org for all your Scleroderma questions!


Centromere Antibodies

  • Please log in to reply
3 replies to this topic

#1 ceciliablaude



  • Members
  • Pip
  • 9 posts

Posted 15 February 2011 - 05:33 AM


Tomorrow I will be going to my appointment with the scleroderma specialist and carry on being scared of the unknown. I have read again lots of the comments of crest stories and antibodies. So my question is that I only had one blood test and I don't know what the doctor asked for, just to check on my antibodies I guess. It says, Ac antibodies, positive centromere, titer 1/5120 ENA positive cenp.

I believe it meant that is that the only thing they found wrong with my antibodies, but after reading your posts I have the idea that maybe I could also have SCLl-70 and others things too. Is that right? Or do you think the blood test can be different over here in Europe?
If they look for abnormality in your autoimmune system I guess they look for everything, don't they? :unsure: :emoticons-group-hug:

Hope to hear from you soon and thanks to all.

#2 Jeannie McClelland

Jeannie McClelland

    Senior Gold Member

  • ISN Support Specialists
  • PipPipPipPipPipPipPipPipPipPip
  • 1,706 posts
  • Location:in the Rocky Mountains of the USA

Posted 15 February 2011 - 08:59 AM

Hi Cecelia,

The first tests that are usually done are for anti-nuclear antibodies (ANA) or anti-centromere antibodies (ACA). Other tests might be done, especially if the results of the first test(s) are ambiguous. We have a very good section on antibodies and scleroderma here. It is worth reading. I think what you are asking is whether or not the one test you have had is enough for a diagnosis. The answer is no. The diagnosis of scleroderma is made primarily by clinical signs and symptom, although antibody testing can point the way to a group of illnesses to look more closely for. We have a very useful brochure with a checklist that you can print out that has a checklist of symptoms here.

When you see the specialist tomorrow, a good thing would be to take a list of your questions with you and also a list of your symptoms. I hope your appointment goes well.

Best wishes,
Jeannie McClelland
(Retired) ISN Director of Support Services
(Retired) ISN Sclero Forums Manager
(Retired) ISN Blog Manager
(Retired) ISN Assistant News Guide
(Retired) ISN Artist
International Scleroderma Network

#3 Joelf


    Star Ruby Member

  • ISN Root Admin
  • PipPipPipPipPipPipPipPipPipPipPipPipPip
  • 4,556 posts
  • Location:West Sussex

Posted 15 February 2011 - 09:29 AM

Hi Cecilia,

Good luck with your appointment with your Scleroderma specialist tomorrow.

I can't really add anything to Jeannie's helpful and informative advice, except to say that I was equally confused about antibody testing when I was first diagnosed and in fact spent many happy hours poring over the details of my blood tests. I think we all want to hear a conclusive diagnosis and feel frustrated when the specialists aren't always able to tie everything up neatly. I've since learnt on my Scleroderma journey that nothing with this bizarre disease is straight forward as it affects each sufferer differently.

Do let us know how you get on with your appointment tomorrow, won't you?

Jo Frowde
ISN Assistant Webmaster
ISN Sclero Forums Manager
ISN News Manager

ISN Hotline Support Specialist
ISN Chat Host
International Scleroderma Network (ISN)

#4 ceciliablaude



  • Topic Starter
  • Members
  • Pip
  • 9 posts

Posted 15 February 2011 - 10:05 AM

Thanks for your answers; and again sorry for my English.

My question was - if they found the anti centromere and no SCL-70, it goes more to the CREST syndrome than the diffuse. If I suffer scleroderma, but as I already have the heartburn and dysphagia, and sometimes Raynaud's syndrome, do they need another blood test to find the SCL-70? :emoticon-dont-know:

Now here in Belgium it is end of the afternoon, I'm going to be busy and won't bother you again with questions today.

Wishing you both a great day . :thank-you-2: