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Progressive Loss of Lymphatic Vessels in Skin of Patients with Systemic Sclerosis (SSc)

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#1 Jeannie McClelland

Jeannie McClelland

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Posted 29 March 2011 - 06:53 AM

Progressive Loss of Lymphatic Vessels in Skin of Patients with Systemic Sclerosis (SSc). In SSc, lymphatic microangiopathy is linked to the progression of skin involvement. The progressive disappearance of lymphatic vessels may have a critical pathogenetic role in the progression of SSc from an early edematous phase to overt fibrosis. Mirko Manetti. The Journal of Rheumatology February 1, 2011 vol. 38 no. 2 297-301. (Also see: Skin Involvement)

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Jeannie McClelland
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#2 mando621


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Posted 29 March 2011 - 07:50 AM

Hi Jeannie,

It is interesting that so much information is available from a skin biopsy. I've also read that the eosinophils in the skin are also a way to see if scleroderma is active in the skin.

I had a biopsy a couple years ago, and the only thing in the report is slight thickening observed. They didn't seem to look at the cellular level of the biopsy at all. I really dislike the idea of going through that again. I have an X scar on my forarm from where they took the biopsy. I called, and the only thing saved is the report.

I'm seeing the sclero specialist on April 20, I wish he had some way of getting that biopsy analyzed differently. Oh well....

I wish this kind of information was read by the rheumatologists I have seen.


p.s. I went to the session last night and had a good play. After a while of playing slower, the main fiddler that organized the session cut loose and I was expecting smoke from his fiddle. At that point I sat back and enjoyed the music.