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Question About SCL70 Test

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#1 docmartenmom


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Posted 14 April 2011 - 06:47 PM

Hi Everyone,

I tested positive for scleroderma in 12/08 (SCL70 test) and now it comes up negative. Could it be Lupus attributing to the initial positive test? I just read that Lupus can cause a false positive on that test - is there data to back that up? I am being treated as if I have MCTD until we cannot rule out scleroderma. I have had numerous tests and the PFT came up slightly abnormal re: diffuse capacity. I am scheduled for a high resolution chest cat scan and cardio testing. Any help would be greatly appreciated - thanks :) Lori

#2 Joelf


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Posted 15 April 2011 - 06:55 AM

Hi Lori,

I've found a couple of links to Antibodies in SLE and Anti-SCL70 antibodies in SLE which I hope you'll find interesting.

Bear in mind though that people can have Scleroderma and other autoimmune problems and yet the blood tests can be negative and vice versa so blood tests are by no means conclusive. Your rheumatologist will probably have a clearer picture once you've had the CT scan and the cardio testing, together with the results of the PFT. I know when I first went to the lung hospital they did all manner of lung and blood tests imaginable and to start with they weren't totally sure that I had Scleroderma. It was only really when they correlated all the information together, plus they could tell the nature of the interstitial lung disease I had by the pattern of ground glass on my lungs, which led them to the diagnosis of Scleroderma.

Do let us know the results of your CT scan and cardio testing.

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#3 docmartenmom


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Posted 16 April 2011 - 11:38 AM

Thanks for the info Jo - hope you are feeling better.

#4 Amanda Thorpe

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Posted 16 April 2011 - 05:07 PM

Hello Lori

Well I have and have always had a negative SCL-70 but have diffuse scleroderma with internal organ involvement. Jo's right in that test results are going to be more telling for you than blood work alone.

Whatever your final diagnosis may be at least your treatment is in good hands.

Take care.
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