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Significant attenuation of macrovascular involvement by bosentan in a patient


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#1 Jeannie McClelland

Jeannie McClelland

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Posted 21 April 2011 - 08:03 AM

Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis (SSc) with multiple digital ulcers and gangrene. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc. Yohei Ichimura, Modern Rheumatology, March 15, 2011. (Also see: Digital Ulcer and Gangrene)

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Jeannie McClelland
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