Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis (SSc) with multiple digital ulcers and gangrene. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc. Yohei Ichimura, Modern Rheumatology, March 15, 2011. (Also see: Digital Ulcer and Gangrene)
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Significant attenuation of macrovascular involvement by bosentan in a patient
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