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#1 scampie5


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Posted 01 June 2011 - 07:03 AM


My specialist has asked my doctor to prescribe N-acetylcysteine. Has any one tried this and if so how did you get on with it? Apparently it is the only agent that has an evidence base in fibrotic lung disease.

Many thanks,


#2 Amanda Thorpe

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Posted 01 June 2011 - 08:33 AM

Hello Lynn

WebMD has an article about N-acetylcysteine. I googled the drug and one of the articles that came up said it can boost the immune system which we don't want in autoimmune disorders.

I thought that the usual treatment for lung fibrosis in slceroderma was cyclophosphamide? I also thought that mycophenolate mofetil (Cellcept) was good for lung fibrosis?

Take care.
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#3 Sweet


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Posted 01 June 2011 - 10:16 AM

I'm with Amanda on this one. I would talk with your doctor about this further.
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#4 Joelf


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Posted 01 June 2011 - 03:33 PM

Hi Lynn,

I've been taking N-Acetyl Cysteine on the recommendation of my consultant at The Royal Brompton Hospital. However, it's not a substitute for the immune suppressants and steroids I take, but another medication which they've prescribed for me.

I've not experienced any side effects from it (as far as I know!) :)

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#5 janey


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Posted 02 June 2011 - 06:40 AM

I'm not familiar with this drug so I did a little research to see if there has been any trials with it and scleroderma. Apparently, there has. Check out the following:

N-acetylcysteine infusion reduces the resistance index of renal artery in the early stage of systemic sclerosis. Acta Pharmacologica Sinica (2009) 30: 1283–1288.

The treatment with N-acetylcysteine of Raynaud's phenomenon and ischemic ulcers therapy in sclerodermic patients: a prospective observational study of 50 patients. Clin Rheumatol. 2009 Dec;28(12):1379-84.

Hope this helps.
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#6 scampie5


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Posted 02 June 2011 - 10:01 AM

Thank you Janey that was very interesting. Hopefully will start it tomorrow which the chemist has ordered for me. Will let you now how I get on. I also may be having intravenous cellcept but not sure yet, as I have hep C; However the doctors have discussed an alternative medication. Will find out more on 9th June. Lynn :thank-you: