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Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis (SSc):


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#1 Joelf

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Posted 14 June 2011 - 10:48 AM

Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis (SSc): potential contribution to perturbed angiogenesis and fibrosis.

EphB4 and EphrinB2 are up-regulated in clinically involved skin of SSc patients, suggesting their participation in SSc-perturbed angiogenesis. TSP1 and TSP2 are up-regulated in both clinically involved and non-involved SSc skin and are constitutively overexpressed in a TGF-β-dependent and hypoxia-independent manner in SSc dermal fibroblasts, suggesting their potential early contribution in SSc pathogenesis. Avouac J, Rheumatology, March 30, 2011. (Also see: Skin Fibrosis)

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