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Skeletal and cardiac muscles involvement in systemic sclerosis.


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#1 Joelf

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Posted 07 August 2011 - 12:10 AM

Skeletal and cardiac muscles involvement in systemic sclerosis.

Patients with systemic sclerosis (SSc) can have muscle involvement in the form of myositis or non-inflammatory myopathy. The muscle involvement can be associated with left ventricular dysfunction (LVD) in patients with SSc, resulting in worse prognosis. Schade L. (PubMed) Rev Bras Reumatol. 2011 Aug;51(4):311-313. (Also see: Cardiac Involvement and Myositis)


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#2 janey

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Posted 09 August 2011 - 09:07 AM

I find this abstract interesting in that both my skeletal and cardiac muscle enzymes are monitored on a bi-monthly basis. The skeletal muscle enzymes (or CPK or CK) are monitored because of the overlap of scleroderma with polymyositis. The cardiac muscle enzymes (CPK-MB) are monitored because 6 years ago they were tested after I received my pacemaker and they were found to be elevated. Also, since I am in chronic atrial fibrillation, my heart muscle is taking a constant beating so to speak. :wacko: Over the years they have gone up and down but last month - for the first time in 6 years - they finally dropped to NORMAL! As a result, my rheumatologist was able to reduce my dose of immunosuppressant. So if you do have heart issues, you might want to ask your doctor about the CPK-MB. Just a thought.
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#3 Amanda Thorpe

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Posted 09 August 2011 - 04:22 PM

How wonderful Janey! :emoticons-line-dance: Long may it continue for you!

The article says "three of the four patients with ejection fraction below the normal reference value had alteration of the muscle strength, atrophy and/or serum creatine phosphokinase (CPK) elevation."

Great, I have LVD and a low ejection fraction, maybe I should ask for the blood tests when next at the Royal Free!

Great article Jo...well not for me! :lol:

Take care.
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