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A false positive on ELISA test?


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#1 Chopper

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Posted 25 October 2011 - 02:49 PM

Hello All,

I realize anything can happen when testing for connective tissue diseases, but I'm just curious if anyone has heard if it's common or not to have a false positive on the Enzyme-Linked Immunosorbent Assay (ELISA) for centromere pattern? It seems the doctor believes I had a false positive since my first ANA didn't show a centromere pattern. In 2 weeks we'll get the results of another ANA test.

I definitely don't have Lupus or RA, so if it was indeed a false positive, I wonder what I have. UCTD? Would there be any chance that Celiac or Hashimoto's would have affected the ANA and ELISA tests?

Chopper
Limited Scleroderma, Hashimotos Thyroiditis, Celiac, Gastroparesis, GERD, and Gastritis.

#2 Shelley Ensz

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Posted 25 October 2011 - 07:39 PM

Hi Chopper,

I'm just not sure how common it is for false positives for anti-centromere. It gets a bit complicated, actually. One question that comes to mind is, in who's opinion is it false positive?

Technically, you would think that doctors would not run an ELISA unless there were some symptoms that would justify it in the first place, right? So then when they get a result that is positive, for something that they may have suspected in the first place, it becomes curious when they then do an about-face and claim that it is false-positive.

Which it might be, if in the meantime they somehow discounted the original symptoms or assigned them to another illness, so the question as to what it means really goes back to the doctor who is making the judgement call in the first place.

Might I add though that it is normal to feel like a ping pong ball in the years leading up to an autoimmune diagnosis. It can be crazy-making if you take any of it too seriously. Basically, the doctors do not want to be wrong and they also don't want to be sued. So some of them tend to walk a very fine line between saying that on the one hand, you might be seriously ill, but on the other hand, you are completely healthy, yet again, you need to have more follow up and testing, which makes no sense if you are, indeed, perfectly healthy, right?

The thing is, in the initial stages they truly don't know what the outcome is going to be. You might be one who is going to turn out a-okay but then again, things might take a turn for the worse. Saying it is false-positive is betting, at least for now, you seem to be pretty much okay, considering, and that they don't have enough information yet to make any firm determination of illness. MAYBE.

That's all totally guesswork on my part, and I am not even qualified to take a medical school entrance exam.
Warm Hugs,

Shelley Ensz
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#3 Chopper

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Posted 25 October 2011 - 08:37 PM

Hi Shelley,

Those were my thoughts exactly. Thanks for perfectly expressing them!

Chopper
Limited Scleroderma, Hashimotos Thyroiditis, Celiac, Gastroparesis, GERD, and Gastritis.

#4 Joelf

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Posted 26 October 2011 - 01:06 AM

Hi Chopper,

I must agree with Shelley's analysis and I do understand how confusing it is with this bizarre disease particularly as it's so difficult to get a firm diagnosis.

I was the same; I spent many pleasurable hours scouring the internet with the details of my symptoms and even more so when I actually got a diagnosis and was sent all the results of the intricate blood tests and other examinations I had.

As Shelley has pointed out, your doctors could be hedging their bets a little as they don't really want to commit themselves to a firm but possibly incorrect diagnosis at this stage.

Kind regards,

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