Skin thickening is a nonspecific manifestation of many different processes including (rarely) early scleroderma, which is mostly symmetrical and associated with Raynaud's phenomenon, nailfold capillaroscopic changes and antinuclear antibodies. PubMed, Curr Opin Rheumatol. 2013 Nov;25(6):692-9. (Also see: Difficult Diagnosis)
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