ssSSc and lcSSc patients share demographic, clinical and immunologic features although differences are mainly due to peripheral vascular manifestations. ssSSc patients should be truly differentiated from early SSc using sensitive and specific studies looking for any asymptomatic organ involvement. PubMed, Clin Exp Rheumatol. 2014 Apr 28. (Also see: Systemic Sclerosis Sine Scleroderma and Limited Scleroderma)
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