Yesterday I got test results from my GP.
I have been experiencing joint pain in my thumbs and wrists. X-rays showed Osteo arthritis in my hands - but the joint pain was coming on in 'flare ups' - so the doctor ran tests to rule out Rheumatoid Arthritis - which my paternal grandmother had bad - and my Dad had also.
(Don't know if it makes a difference - but I'm in Canada).
The only thing that was "off" in all the tests, she said - was the ANA score, which was positive.
Nuclear Ab/ANA: 5.0 (High)
(Moderate Positive 2.0-5.9)
There is nothing that shows any pattern - and no titre is shown either. (will require another appt with GP to get those values)
Because the ANA was positive the lab did a SCL-70 which was also positive, (among others tests which were all within range):
Scl-70 Ab 268 (<100) U/ml (High) Note: New Method (Multiple) and Reference Interval
There was also an Anti-CCP test done - but (strangely?) it says "For Physician Only" - and gives a number for the doctor to call to 'discuss results' with the pathologist. I have no idea what that means - or why I cannot see the value. (I understood Anti-CCP was pretty specific to RA? My Rh factor was negative).
Had I realized it, before I left the office, I definitely would have asked about it.
I have what I think is microcytic anemia (which I was told was a hallmark of RA):
Red Blood Count (H) - 5.2 (3.7-5.0)
MCV (L) - 76.2(28.3 - 33.5) fL(LOW)
MCH (L) - 25.8 (28.3 - 33.5) pg (LOW)
Platelets (L) - 144 (147 - 375) 10*9L (LOW)
My doctor was very serious - and very concerned about the Scl-70.
She has referred me to a Rheumatologist - though it will take 2 - 3 months to see her.
I understand that the SCL-70 is pretty specific, but could it possibly indicate Rheumatoid Arthritis and not Scleroderma?
What are the percentages for 'false positives' with the SCL-70 anti-body test?
Are the 'new method multiplex' tests always accurate?
Exactly what kind of joint pain do you get with Scleroderma?
I'm so confused!