Jump to content

Welcome to Sclero Forums!! How may we help you?


Methotrexate dose and effectiveness

  • Please log in to reply
2 replies to this topic

#1 greypilgrim256


    Senior Bronze Member

  • Members
  • PipPipPip
  • 75 posts
  • Location:New Jersey

Posted 28 November 2014 - 04:09 PM

Hello all, and Happy Thanksgiving.  I'm currently up to my 5th week of Methotrexate and it seems to be going well.  I am only on 7.5mg a week, which my understanding is a very low dose. 


Has anyone been on a similar dose?  Was it effective? 


I am currently weaning my Prednisone down and am worried about the terrible joint and muscle pain coming back as I wait for the MTX to start working, which I understand can take 3-6 months. 




#2 Joelf


    Star Ruby Member

  • ISN Root Admin
  • PipPipPipPipPipPipPipPipPipPipPipPipPip
  • 4,846 posts
  • Location:West Sussex

Posted 29 November 2014 - 06:34 AM

Hi Greypilgrim,


I'm very pleased to hear that the Methotrexate is going well; I understand that it can take a while for the medication to work and for any side effects to settle down. It is possible that you may experience more joint pain as you wean down the Prednisolone; however, as you're no doubt aware it should be done very gradually and so hopefully by the time you've got down to a low dose or been able to come off it altogether, the MTX should have kicked in.


If you can reduce the Prednisolone, I think it would be beneficial: unfortunately, I'm now experiencing another delightful little side effect of the steroids in as much as I have developed Avascular Necrosis in my hip joints necessitating bilateral hip replacements. That's curtailed my activity somewhat!!  ;) :o


Kind regards,

Jo Frowde
ISN Assistant Webmaster
SD World Webmaster
ISN Sclero Forums Manager
ISN News Manager
ISN Hotline Support Specialist
ISN Chat Host
International Scleroderma Network (ISN)

#3 Amanda Thorpe

Amanda Thorpe

    Platinum Plus Member

  • ISN Senior Support Specialist
  • PipPipPipPipPipPipPipPipPipPipPip
  • 2,925 posts
  • Location:U.K.

Posted 29 November 2014 - 03:04 PM

Hello GreyPilgrim


I was on methotrexate for about 10 months and just tried it again recently for a month. First time round it made me nauseous for a few days after the dose for a few weeks then no problems until month 10. As with mycophenolate I had few problems with immunosuppressants but the hit intolerable ones. This time it wiped me out immediately so that I was just asleep! I was trying it as a last ditch attempt to heal my foot ulcers, it didn't and as as agreed by my husband I stopped taking it again.


Many people take it without incident and you could be one, let us know how it goes.


Take care.

Amanda Thorpe
ISN Sclero Forums Senior Support Specialist
ISN Video Presentations Manager
ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist
International Scleroderma Network (ISN)