Although microvascular disease is a hallmark of SSc, mechanistic insights explaining the presence of accelerated atherosclerosis, and the presence and extent of macrovascular disease in SSc patients are lacking and future challenges will be to unravel the genetic, environmental and ethnic determinants of such processes. PubMed, Curr Opin Rheumatol, 2014 Nov;26(6):653-7. (Also see: Atherosclerosis)
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