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Epitope specificity determines pathogenicity and detectability of anti-PDGFRa autoantibodies in systemic sclerosis.

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#1 Joelf

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Posted 25 May 2015 - 09:47 AM

Epitope specificity determines pathogenicity and detectability of anti-PDGFRa autoantibodies in systemic sclerosis.

 

Agonistic anti-PDGFRa autoantibodies are enriched in SSc sera and recognize specific conformational epitopes, that can be used to discriminate agonistic from nonagonistic antibodies and block PDGFRa signaling in SSc. PubMed, Arthritis Rheumatol, 03/25/2015. (Also see Autoantibodies)

 

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