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Low positive ANA


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#1 Tbhof

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Posted 20 October 2015 - 04:21 AM

Hi everyone. I went back to my doctor to redo the ANA as I wasn't sure what method was used. It came back 1:80 speckled. ENA was also run. In that, Scl-70 and Ribonucleoprotein (RNP) came back negative as well as for Sjogrens.
Can anyone tell me what speckled means? What a low reading may mean? Thank you!



#2 judyt

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Posted 20 October 2015 - 10:16 AM

Hi,

 

When I was diagnosed my ANA result was Centromere Pattern 1:1280.

 

As far as I know, not having worked in a lab. since 1966!!, these patterns are created when the sample is treated and then looked at under a microscope.

Speckled and Centromere are patterns which indicate Scleroderma (and other things too) and the numbers expressed in a ratio indicate the 'strength' of the reaction.

So the way I understand it 1:80 is low and 1:1280 is stronger.   I don't know how high they go, could be astronomical or not!!   It would be interesting to hear what ratio others on here have got.

 

This is a very simplistic description because I haven't even got a current first aid certificate, and my memories are from a VERY long time ago.

 

Best wishes

Judyt



#3 Margaret

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Posted 20 October 2015 - 02:22 PM

Hi....Gareth's ANA was positive, speckled pattern, diffuse cytoplasm, 1:80, per Dr Metzer's lab.  Scl-70 and ACA were negative.  Anti-RNA 1/111 has been positive 3 times.  With those results and esophageal dismotility + internal involvement, he does not have the *scleroderma* diagnosis, but UCTD. 

 

Hi Jo and Amanda....we got home last week. Loved England and Ireland!!

 

Take care, Everyone.

Margaret

Mom to Gareth, 27 years old, DS/ASD



#4 Joelf

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Posted 20 October 2015 - 10:13 PM

Hi Tbhof,

 

As with a lot of the antibody tests, they really do need to be taken in conjunction with all the clinical symptoms as well.

 

I've found a useful link for you about the Antinuclear Antibody test which explains about the speckled antibodies in more detail. It does sound as though your results are good as the readings do seem to be quite low (I think 1:40 is considered within the normal range, so 1:80 does seem quite acceptable.)

 

Kind regards,

 

 
 


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#5 Joelf

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Posted 20 October 2015 - 10:13 PM

Hi Margaret,

 

I'm so pleased you had a lovely holiday and arrived back home safely.

 

How lucky you were with the weather; it's pouring with rain today, as per usual!! :wink:

 

Here's a special "hello" for Gareth and I'm really hoping his operation goes well.

:hug-bear: :hug-bear:


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#6 Buttons

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Posted 21 October 2015 - 07:42 AM

Hi 

 

My bloods came back exactly the same as yours Judy! I was told this was the Limited Cutaneous Systemic Sclerosis. Mine was also diagnosed along with the medical notes taken and a physical examination.

 

Buttons



#7 Tbhof

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Posted 21 October 2015 - 11:11 AM

Some labs say 1:80 is a negative result. My primary doctor says its insignificant. I'm just not sure what to think!!

#8 Shelley Ensz

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Posted 22 October 2015 - 06:53 AM

Hi Tbhof,

 

Systemic scleroderma is a clinical diagnosis, meaning that it is based upon symptoms and not upon bloodwork.  A person could have off-the-charts positive antibodies but without any telling symptoms, would not carry a diagnosis of scleroderma -- a suspicion of it possibly occurring at some point, of course, but that is very different than actual diagnosis.

 

As well, a person can have entirely negative antibodies but still be diagnosed with scleroderma, based upon symptoms alone.

 

Since your antibodies are "insignificant", or possibly even "negative", then the question reverts back to your present symptoms.

 

Autoimmunity can come and go; it is not always a continually persistent thing. It's better to think of antibodies as a clue, one that sometimes (but not always) solves the mystery, but for some of us the clue that solves it, especially in the beginning, isn't the lab work, but rather other things, like unmistakable tight skin or lung fibrosis, combined with other symptoms.  See Difficult Diagnosis.


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