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I'm sorry you have rapid onset diffuse scleroderma and that you are also encountering some medication issues. Unfortunately most treatments for very severe diseases also run the risk of being quite toxic, so it is a constant weighing of the risk versus benefit.
Thank you for your interest in Resunab, and for mentioning it. I thought it might be helpful to explain it a bit more for others who are curious about it.
As it happens, Resunab is just starting Phase 2 clinical trials in the U.S., to see if it might be effective, and safe, for diffuse scleroderma. Pre-clinical studies looked promising for reducing inflammation and fibrosis without suppressing the immune system.
Unfortunately we have seen many potential treatments complete even phase 3, appearing to be quite positive, before being proven to be of no use for scleroderma. That is because the illness has a natural course of waxing and waning, even without any treatment at all, which usually causes great confusion, making treatments appear effective which in the end are shown have no effect at all. That's not to say this will happen with Resunab, it's just a disclaimer for scleroderma clinical trials in general.
Although Resunab (by Corbus Pharmaceuticals) has been fast tracked by the FDA in the U.S., the clinical process still remains quite long, especially for those of us who are eager for an effective new treatment right now. Phase 2 for this trial just started recently, and is scheduled to take 18 months. Then Phase 3 clinical trials generally take about 3 years, after that.
The FDA Drug Approval Process explains more. And we have many more listings of current Scleroderma Treatments and Clinical Trials on our main website.