42 year old male.
2 years ago I was completely healthy and very active.
Then developed rapidly progressive neuropathy consisting of biopsy positive small fiber neuropathy; paresthesias; my hands and feet and legs constantly falling asleep; sometimes fasciculations. But all nerve conduction studies negative, EMG negative.
Developed Raynaud's phenomenon.
Developed finger and hand pain.
My hands (palms) developed red mottling, and they feel painful and tight, and are often ice cold no matter what.
3 months ago I developed the sudden onset of terrible chest pain, on high dose prevacid I'm getting only modest relief and they are planning to do an esophageal motility study. Separate from that I also have this weird tight stretch feeling from the center of my chest, across my upper chest, across my shoulders, into my forearms, on both sides.
I also developed a number of ligament and tendon problems that have not gotten better.
I have had every test, every exam, scan, LP, you can imagine. I am completely negative for ESR, CRP, full rheum panel all antibodies negative.
I have seen 3 rheumatologists, 3 neurologists, a pulmonologist, cardiologist, chiro, rolfer, masseur, etc.
So: any thoughts or possibilities? Can symptoms continue to evolve and progress for many years before declaring themselves with renal dysfunction, pulmonary or systemic hypertension, skin tightening?