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Confused by lab results...is it Scleroderma?

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#1 Smb117



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Posted 25 July 2016 - 02:29 AM

I had labs ordered by my Rheumatologist in March 2016. The results were all in normal range (including ANA and SCL-70 Antibody). The only lab result that was out of range was my Vitamin D...it was 11!


Fast forward to July 2016, my rheumatologist sent me for follow up labs. My Vitamin D was normal but my SCL-70 was Positive 2.4 (or 240?). My ANA was again negative. I've read that a negative ANA and positive SCL-70 is suggestive of Scleroderma and the reason my SCL-70 was negative in March was either a false negative or Scleroderma was "active" at the time.


Can someone please help me understand? I don't want to depend on Google for information so I'm hoping this forum can help! I haven't heard from my Rheumatologist yet, but I'm nervous about the results. I've heard scleroderma is very serious! I do have several symptoms of it as well. Thank you for reading my post.

#2 Joelf


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Posted 25 July 2016 - 08:45 AM

Hi Smb117,


Welcome to these forums!


I'm sorry that you've had worrying blood test results. However, I would emphasise that the blood tests are only a very small part of the diagnosis for scleroderma, which should really have the clinical signs included, and it is perfectly possible to have positive results and yet never go on to develop the full blown disease and vice versa, as many of our members can testify.


We actually have numerous threads on this subject and if you go to our search engine at the top right hand corner of the page and type in "antibodies" it will bring up a lot of threads and information. I've included a link to our medical page on Diagnosis of Scleroderma, which I hope you'll find helpful and interesting.


Kind regards,

Jo Frowde
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#3 Shelley Ensz

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Posted 25 July 2016 - 10:02 AM

Hi Smb,


I think it would be appropriate for you to schedule an office visit so that you can discuss the test results with your rheumatologist, and see whether they want to do additional baseline testing, or perhaps even begin treatment of some sort. 


It's not always necessary to treat scleroderma, usually symptoms are just treated, especially in the beginning stages. But if you haven't had a full round of baseline testing (for heart, lungs, kidneys), now would probably be a good time to schedule it.


Bear in mind that your symptoms are far more important than your blood work, as Jo said. If your rheumatologist isn't a listed scleroderma expert, you may want to discuss with them a possible referral to a scleroderma center.



Warm Hugs,

Shelley Ensz
Founder and President
International Scleroderma Network (ISN)
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