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Scl70 Antibody: Does It Mean Diffuse Scleroderma?

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#1 memeto2


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Posted 01 May 2007 - 09:04 AM

hi everyone,its been awhile since I have been on here,its good to be back.my question is if you are positive for having the SCL70 in your blood, does that mean there is a good chance that you do have diffuse scleroderma??i did go to the link on SCL70,but it didn't really say.thanks alot for answeringtake care memeto2

#2 WestCoast1


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Posted 01 May 2007 - 01:28 PM

Hi there,


Scl-70, along with other labs can indicate what kind of Scleroderma that one has or may get in the future. It does not mean that one will ever get scleroderma of any kind even if the lab is positive for Scl-70. It really depends on what symptoms you are suffering from. Autoimmune disease is so illusive and the symptoms are sometimes so vague that these labs are all we have to lead us to the diagnosis, and in turn proper treatment.

There are links that better describe this, I am sure that someone here will supply an appropriate link for you. Hope this helps.



#3 Jessica


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Posted 02 May 2007 - 05:36 AM

I tested positive for SCL-70 and on the ANA but was told I don't have scleroderma. Instead I was diagnosed with Palindromic Rheumatism.

#4 janey


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Posted 07 May 2007 - 04:57 AM

Looks like Erin and Jessica have already provided a couple of good answers, but I'll throw in my two cents worth. My sclero antibodies are less than 1, but I definitely have systemic sclero with heart and lung involvement. So we really can't trust the antibodies testing to provide definitive answers for us. They are indicators and help the doctors know what to look for and where to look, but most doctors do not use just the bloodtest results as a solid diagnosis.

You might want to check out this link on auto-antibody patterns that is on our Antibodies page. It's pretty interesting.

Janey Willis
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International Scleroderma Network (ISN)