Thalidomide Proposed To Shut Off Scleroderma
Posted 08 July 2007 - 07:43 AM
I'm asking because my insurance said a big, fat NO to SCOT. Thank agains!!
Posted 08 July 2007 - 11:28 AM
The ISN website has some info on Thalidomide for scleroderma:
On the Scleroderma Clinical Trials: Positive Results page:
Enrollment closed. Positive initial results from 2000, larger study needed.
T cell immunity in collagen biosynthesis of scleroderma This project studies the immune modulatory effects of the drug thalidomide on the fibrosis of scleroderma. New York University School of Medicine.
This item has an interesting PDF file about the trial. You will need Acrobat Reader to read it. The doctor concerned is Dr. Stephen J Oliver, and you may be able to write to him to find out more if you are interested.
The webpage Medications for Scleroderma has this item:
Thalidomide as an immunotherapeutic agent: the effects on neutrophil-mediated inflammation. Thalidomide has been rediscovered as an immuno-modifying drug. These findings shed new light on the anti-inflammatory properties of thalidomide and suggested that they may inhibit granulocyte-mediated tissue injury. PubMed. Curr Pharm Des. 2005;11(3):395-401.
I hope this helps.