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Biomarker for Diffuse Scleroderma skin has been discovered!


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#1 Clementine

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Posted 19 July 2007 - 05:36 PM

Hello,
I am always trying research my ANA pattern and figure out what these are markers for and what it all means to me.
I am high-titer nucleolar ANA and positive THTO antibody. I can find information on nucleolar ANA but nothing on THTO antibodies.
Anyone have these and does anyone know where to find more information?
Thanks,
Jennifer

#2 summer

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Posted 19 July 2007 - 06:48 PM

Hi Jennifer,
I'm not sure what the THTO stands for, but here is a link for Auto-Antibody Patterns.

hope this helps
Celia

#3 Margaret

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Posted 20 July 2007 - 12:42 AM

Hi Jen ,

Here's a site I go to for 'funky' blood work.

http://www.rdlinc.com


"Utilities: The Th/To Ab is present in 10-19% of patients with Diffuse Cutaneous Systemic Scleroderma (SSc) and in 3% of patients with primary Raynaud's Disease. It has been shown to be highly specific for patients with SSc. ""

Have a good day, Everyone.
Margaret



#4 janey

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Posted 20 July 2007 - 02:56 AM

Jen,
Celia and Margaret have provided a couple of great links, both of which are found on our antibodies page.

 

We're learning everyday aren't we?

Big Hugs,


Janey Willis
ISN Support Specialist
(Retired) ISN Assistant Webmaster
(Retired) ISN News Director
(Retired) ISN Technical Writer for Training Manuals
International Scleroderma Network (ISN)

#5 Margaret

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Posted 20 July 2007 - 04:01 AM

<<We're learning everyday aren't we?>>

Janey ,

I can't even begin to imagine how lost I would have been without this site and the internet!!!

Take care, Everyone.
Margaret

#6 LunchLady58

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Posted 20 July 2007 - 05:06 AM

Hi Jen,
I too have a pos ANA (1:640) w/nucleolar pattern. I didn't have the test for THTO, but here is a list of the tests I gave 8 vials of blood for yesterday:

Anti DSDNA
Anti SSA SSB
C3 C4
Parvovirus
Anticentromere Antibodies
Anti SCL70
Antihistone
ENA
Lupus Anticoagulant/anticardiolipin

Whew! When I got up to leave, the lab tech said she would be keep me in her thoughts.
Do these look familiar to everyone?
I'm guessing, from my reasearch, that the Anti SCL70 is the big red flag my rheumatologist will be looking for. The others look like she is checking for Lupus.

Good luck to you! :)
ANA+, Nucleolar pattern, anemia.

#7 Clementine

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Posted 20 July 2007 - 05:48 AM

LL,
Hello and welcome!

I am negative for slc70. I am not sure that if one is positive that it is a red flag...but you can be without it and have scleroderma.

I was so whacked out when I had tests trying to figure out what was going on (mine sent me to a 3 week stay in the hospital) that I don't really know what all was tested for. I know I was tested for Parvo.

Take care,
Jennifer