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Scl-70 Question


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#1 Nelly

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Posted 06 August 2007 - 11:51 AM

Once you test positive for this, can it go away? I know that the ANA can be positive and negative at varying times. Is the Scl-70 the same way or once you have it, you have it?

I was negative when my symptoms first started. Then 6 months later it was positive and has been since.

#2 janey

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Posted 06 August 2007 - 04:58 PM

Nelly,
That's a very good question. It is possible for the levels of antibodies to change within our system especially once we start a treatment. I was diagnosed with systemic sclero 4 years ago, but they didn't check the scl-70. My ANA was high and still is. However last year they finally checked my scl-70 and it was negative. Wish I knew if it were positive 4 years ago. I've been on an immunosuppresant of one kind or another for 4 years, so that may have affected its level. I see my rheumatologist on Wed and if I remember (OH memory - another thing that's going -:) ) I'll ask about varying antibodies level.

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Janey Willis
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#3 janey

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Posted 09 August 2007 - 08:52 AM

Nelly,
I saw my rheumatologist yesterday and asked him about scl-70 going up and down. He said absolutely. Any bloodtest can go up and down. In the conversation I asked if my scl-70 was checked 4 years ago, so he looked it up. Yes it was checked and it was negative then as it is now. He did say that a low percentage of people with scleroderma test positive for scl-70, that's why he uses symptoms more as an indicator as to what you have and how things are progressing. My aldolase is positive which is an indicator of MCTD which I have.

Hope this helps answer your question.

Big Hugs,
Janey Willis
ISN Support Specialist
(Retired) ISN Assistant Webmaster
(Retired) ISN News Director
(Retired) ISN Technical Writer for Training Manuals
International Scleroderma Network (ISN)

#4 Nelly

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Posted 09 August 2007 - 09:48 AM

Thank you Janey! Very interesting. I can mark that question off my ongoing list of curiosities. :P Frankly, it doesn't surprise me that it can fluctuate....it seems nothing regarding autoimmune disease is concrete!

I hope your appt. went well.