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Systemic Sclerosis Patients Have Activating Antibodies Targeting Both Endothelin Receptor Type A And Angiotensin Ii Type 1 Receptor


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#1 Guest_Jude the Grouch_*

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Posted 04 October 2007 - 09:32 AM

Systemic Sclerosis Patients Have Activating Antibodies Targeting Both Endothelin Receptor Type A And Angiotensin Ii Type 1 Receptor Predicting Worse Prognosis. Anti-AT1R and anti-ETAR antibodies are a biomarker for severe disease and worse prognosis and could explain pathogenic features found in systemic sclerosis. The detection of these antibodies could identify SSc patients that might benefit from a receptor blockade or from a specific modulation of the antibody-receptor interaction. G. Riemekasten OP0162 EULAR 2007. (Also see: Causes of Scleroderma: Endothelin, Antibodies,and Prognosis)



#2 peanut

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Posted 04 October 2007 - 12:57 PM

This is an interesting article. I take Letairis for PH. It's an endothelin receptor antagonist (ERA). I wonder if this is the same type of endothelin receptor blockade they refer to in the article?

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