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Positive Ana

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#1 relicmom1


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Posted 09 October 2007 - 06:16 AM

Hello everyone! I have been absent for awhile...been battling a pretty bad flare...oh well...my question is this...I have been diagnosis with CREST and For years I have always had a positive ANA with the centromere pattern. Well, on my last visit with my rheumatologist the usual bloodwork was drawn ( I get it every 3 months) and now instead of the centromere pattern it is now the speckled pattern. I haven't seen my rheumatologist yet to ask if this happens. Has anyone ever had this happen? Does this mean a progression?? I find it curious that this was also the time of my flare. Any ideas anyone?????
Peace :)
Barbara aka relicmom1

#2 Nelly


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Posted 09 October 2007 - 07:47 AM

I believe the pattern can vary just as the ANA can. Mine started off homogenous, now it's speckled. Also, you can have more than one pattern show up.

I don't think it has anything to do with progression.

#3 Sweet


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Posted 09 October 2007 - 09:05 AM

Hi Barbara,

No it doesn't necessarily mean progression, but can mean that your disease could be shifting to another diagnosis, or to include other symptoms. My ANA pattern has shifted through all of the patterns, but mainly seems to be staying with the centromere.

My rheumatologist whom I'm told is top notch and one of the best, doesn't put much weight in the ANA, once positive that gives him reason to to search out other tests, but he doesn't use the ANA solely for diagnosis. As a matter of fact my last one was negative, but I still have the disease.
Warm and gentle hugs,

ISN Support Specialist
International Scleroderma Network (ISN)

#4 tintin


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Posted 09 October 2007 - 10:35 AM

The test could also have been misread, speckled and centromere are close.
keep on smiling


#5 janey


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Posted 09 October 2007 - 12:54 PM

Here's a link I found on our Antibodies page that kind of explains what the patterns for ANA mean.

Auto-Antibody Patterns

My rheumatologist is like Sweet's - he goes by symptoms mostly. I have no idea what my pattern ever was. Also, after looking at all the variations of ANA patterns, Crawler is probably right on. If the same technician didn't interpret your latest test, then she or he could have read it differently. The best way to get an accurate test of any kind is to have the same person interpret each time - and we know that is something that will never happen. blink.gif

I'm sorry you've been battling with a nasty flare. I hope it turns around soon.

Big Hugs,

Janey Willis
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(Retired) ISN Assistant Webmaster
(Retired) ISN News Director
(Retired) ISN Technical Writer for Training Manuals
International Scleroderma Network (ISN)

#6 Patty


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Posted 09 October 2007 - 01:08 PM


When all this sclero stuff started for me, I was told that ANA really was not important because someone with no autoimmune disease could test positive on the test. Wonder why some put so much on it and others feel its not accurate.

If Life hands you lemons, make lemonade.

Hashimoto's thyroiditis, Limited scleroderma, Dermatomyositis. Diastolic Dysfunction, dysphagia, Fibro, restless leg. Lupus is a maybe.

#7 eah


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Posted 09 October 2007 - 01:57 PM


I have heard from many people and specialists not to put a whole lot of emphasis on ANA or patterns. I had previously positive ANA with centromere and quite high. My symptoms worsened and then I tested negative. Most Scleroderma specialists look at symptoms vs. blood work. I have been told blood work only helps to confirm, but they really look at symptoms.