Posted 12 October 2007 - 11:14 AM
I also have a positive ANA.
Posted 12 October 2007 - 03:12 PM
Welcome to the forums! Based on your question, it appears that you are in the testing or diagnostic phase. Have you been diagnosed with anything?
I couldn't find any relationship between scl-70 and Raynaud's. In most of the literature and in some of the articles on the ISN antibodies page, scl-70 is said to be scleroderma specific; however, not everyone with scleroderma has a postive scl-70. A positive ANA (auto-nuclear antibodies) indicates that an autoimmune disease may be present. However, there are members of this forum that have a negative ANA and scleroderma. I have a positive ANA and a negative scl-70. I have systemic scleroderma (SSc).
Again, welcome! So glad that you have joined us. Please tell us more about yourself.
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Posted 12 October 2007 - 08:27 PM
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Posted 13 October 2007 - 05:21 AM
Welcome to the Sclero Forums! Really really glad to have you with us. You will find so much information here, support and people who truly understand what you are going through.
Posted 13 October 2007 - 08:36 AM
I have a positive scl-70 and do not have raynauds. My test was 42. I also have a positive ANA at 1:640. Hope this helps.
If Life hands you lemons, make lemonade.
Hashimoto's thyroiditis, Limited scleroderma, Dermatomyositis. Diastolic Dysfunction, dysphagia, Fibro, restless leg. Lupus is a maybe.
Posted 14 October 2007 - 05:07 AM
I have been at this for several years. I just like coming onto the forums every now and again to see if new info. has been learned. I have found over time that I get more info. from the patiences experiences. Plus the info. is more condensed a lot of people a lot of Dr. visits, a lot of shared experiences.
I have had raynauds for about 10 years. This was my first problem. I just keep waiting for science to catch-up with me.I knew then that a positive ANA was not a factor of raynauds but science is full of contradictions.
I have not been tested for an ANA in the past year. My Dr. said I have tested positive enough times. Not in titers reg. 0-99 and I have been in the 500's. My SCL-70 test 0-99 reg. I have tests in the 300's.
I have the usual complaints.
Thanks again This seems like a nice place,
Posted 16 October 2007 - 03:27 AM
I am at a junction right now. My doctor relocated. There is no rheumatologist in the area; I would need to travel. So I guess that what brings me back to the "forums".
So just for my clarity. raynauds alone would not produce the positive labs?
My mother also has some sort of autoimmune disease but they cannot give her a clear diagnosis. Due to her age (82) she does have some degenerative joint disease. Her BP is all over the place. She has the other usual complaints very swollen hands, fatigue, cold toes, terrible stiffness at times that can last for weeks. After being on prednisone for a couple of years the one thing that finally gave her some relief is hydroxychloroquine. Also my grandparents were diseased before I was born and Ijust learned my mother's mother died from Brights disease. My mother's labs come back almost normal (go figure).
So now I have to figure out what steps I need to take that is best for me and my family.
I have intestinal issues and high BP along with the previous complaints I stated in my earlier post. It looks like for now I have sine scleroderma with a crossover of lupus. Without skin involvment will the doctor ever really know for sure?
Posted 16 October 2007 - 04:43 AM
A positive raynaud's will not give you a positive scl-70 antibodies or vice-versa.
Raynaud's can be caused by a number of things or appear on its own. So many autoimmune illnesses are intertwined and sometimes it is very hard for the doctor to single out just one in order to give you a diagnosis. Sometimes (unfortunatley) we never get a solid "clear-cut" diagnosis. On the other hand that is not always a bad thing. The reason that one gets a diagnosis is because one trait stands out amongst the rest...but a Mixed Connective Tissue Dissorder has a good prognosis, so that is not such a bad place to be either.
Hydroxychloroquine (Plaquenil) is a good general medication that can help with several symptoms of autoimmune related issues. It helps with the joint pain, sometimes the stiffness and fatigue.
I am sorry to hear that you are just now learning about your family's unfortunate medical background. Just because many of them had an autoimmune dissorder, doesn't meant that everyone in your family will...you may even exhibit the antibodies because it is in your family, but never show any signs of an active illness. Just something to remember.
Please stay in touch and let us know how you are doing. If you do find yourself getting worse, it is always worth the travel to the doctor.
Posted 16 October 2007 - 05:56 AM
Posted 17 October 2007 - 11:33 PM
If you have tested Positive for the SCL-70 test, than why have you been diagnosed with having Limited Scleroderma? , I thought that SCL-70 test was for Diffuse?.
Posted 23 October 2007 - 02:38 AM
I have some COPD, high BP, raynauds, three years ago my hands started swelling and I had some nodules on them,I have constant pain;similar to carpel tunnel syndrome, GI issues, and "toothache " like pains in my knees, wrist, toes and ankles. (This has since improved some) and sicca.
If I over use my voice I will get hoarse. I cannot read a story to my son past about 5 pages because my throat starts to hack constantly even if I drink water. So who knows what's really going on?
But thank you for all that replied to my post,
Posted 20 August 2009 - 04:35 AM
I also have a positive for Scl-70 and C-3 complement runs slightly low 74-84 with normal being 90- +.
I have had 2 positive SCL-70 and 3 negative SCL-70 test after the positives.
I have fatigue sometimes, and just weird little things that happen. A little pain that comes and goes
in my back area all over. Everything internally has been looked at. Nothing wrong.
All other labs are good.
Occasionally in the past when I am run down my platelets have dropped below the 150,000 mark.
I am 37 years old and the mother of Twins that are now 5 years old.
I get just a little cold and my hands will turn splochy with White and Red.
I am not sure if it is Raynands, but my hands are never blue.
I am going to my third rheumatologist Sept 2nd, and my third rheumatologist in Oct at Emory.
No clinical symtoms. My friend that is a cardiologist did find just a little extra fluid on my
periocardium 30cc extra. I have 90 cc and normal is 60cc.
Does anyone else have a positive scl-70 and how long?
I am find that the doctors don't understand Scleroderma.
Posted 21 August 2009 - 12:44 PM
How low is your c3-complement? Mine is usually 6-10 points under what is normal.
I think it has to do with how well your body fights off infections.
Posted 21 August 2009 - 01:04 PM
What are the doctors telling you? I am searching for a scleroderma specialist and would like to go to someone that has seen everything.
We do not have one here in Ga. Does anyone know of a great sclero specialist. I have seen this list, but I want names and experiences too.
Referrals for a person is the best. Scl-70 positive and c-3 complement slightly low.
Anyone please give a suggestion. Thank you, TonyainGa
Posted 22 August 2009 - 02:00 AM
How long have you been positive and no symptoms? If looks like you joined in 06.
I had a positive in 07, and negatives since, but I had a weak moment the other day. I went to
any lab test and ran scl-70, c-3 complement, and thyroid panel because I wanted to check.
I just feel tired which is starting to make me wonder. I am 37 and had to do fertility drugs to get pregnant, and I wonder
if this did not send me in to a spiral since I could not get pregnant.
I took lots of hormones trying to get pregnant.
Anyway, please tell me more about your scl-70 experience? Thank you, Tonya
Posted 22 August 2009 - 03:49 AM
I've seen other postings on this site where people with far more symptoms, but no clear skin manifestation or Raynaud's/capillary looping, have been told they have a 20% chance of their undifferentiated connective tissue disease turning into scleroderma, or, lupus, or Rheumatoid arthritis. You can search the forum postings under 'scl70' to see who else has posted on this issue. It's becoming clear to me that, as scl-70 positive individuals, there is far more variation in our overall clinical experience than most research summaries or literature reviews suggest. For example, it is possible to be healthy even with a positive ANA and scl-70.
Posted 22 August 2009 - 04:27 AM
I don't think it can be stated often enough that antibodies don't 'make' a diagnosis. We've had a lot of members with positive ANA and/or Scl-70 results and no symptoms; with positive results and mild symptoms that could just as easily be attributed to something other than scleroderma; and negative results and a definite diagnosis (that's me - I've never tested positive for Scl-70). Did I cover all the permutations? I was trying to count on my fingers, but they've got cherry jam on them.
I know it is really rotten to feel that something is going on and not know what it is~ Been there, done that. I've even got the T-shirt. The one thing we do know is that stress is bad for everybody and we can ruin our enjoyment of life and every day's little pleasures by worrying about something that may never happen. The best advice I can give you is to get screened by an expert at some point. If there is no diagnosis forthcoming, then relax and enjoy some watchful waiting.
As a dear friend once told me, worrying is like buying insurance on a house you don't own.
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Posted 22 August 2009 - 07:25 AM
Thank you for the post. I need to hear that because everything you read gives you poor prognosis. I posted on Thursday that I had gone to the Any Lab Test place and had them run another Scl-70 just to make me feel better emotionally. I have read this not a good tool to use or should not be.
Anyway, it made me feel better. I had my 4th negative over a 2 year period, however, my c-3 complement is at 83 normal being 90. I also ran a thyroid panel and was good.
Okay, I am on the way back up from my low.
I have always taken care of patients and been able to make things better for others. It has been so hard for me to be a patient.
Also, I have always been in control of what I eat, how much I exercise, and just doing the right thing. However, I am learning there are things that you can't control. It is just ironic that I have controlled my environment, but can't control my body's genetics. I am not sure if I said that right because I am not really good with words.
I am glad I have found this place and wish I had only done this a year sooner. I will only keep hoping that there will be a cure or a miracle will come.
I kept looking at this board, but would never post.
Thank you, Tonya