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Biomarker for Diffuse Scleroderma skin has been discovered!


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Help Plz ... What Does This Mean?


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#1 Janice

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Posted 22 October 2007 - 11:26 AM

I had a positive ANA and a positive DNA antibody of 4.8. What does this mean? It's like a foreign language to me.

#2 janey

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Posted 22 October 2007 - 04:32 PM

Janice.
ANA stands for anti-nuclear antibody. Antibodies are proteins in our blood. The immune system uses them to identify and neutralize viruses, bacteria, or other foreign invaders. If we have too few or too many of a certain type of antibody, it could mess up the immune system and how it works. A positive ANA indicates that a problem with autoimmunity could exist. I found that a positive DNA antibody (>4) could indicate Lupus. As with most things, antibody measurements are not 100% reliable but they do help the doctor in looking at other things for a proper diagnosis.

I hope this helped.

Big Hugs,
Janey Willis
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(Retired) ISN News Director
(Retired) ISN Technical Writer for Training Manuals
International Scleroderma Network (ISN)

#3 Janice

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Posted 22 October 2007 - 11:24 PM

That clears the muddy water a bit ... lol ... thanks for the info.

#4 summer

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Posted 22 October 2007 - 11:40 PM

Hi Janey,
Does a doctor have to specifically run a DNA test to check for antibodies for lupus?, or is it run in the same panel as ANA?
Is the DNA test the same as everybodies DNA(gene), or is it something different to that?

Many thanks
Celia :mellow:

#5 janey

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Posted 23 October 2007 - 03:50 AM

Celia,
Here's a site from our Antibodies page that might provide some answers for you.

Patient Information. ANA Testing

Here's a statement from this site:

In patients with suspected or diagnosed systemic lupus erythematosus, additional testing may be performed to determine the presence of three specific types of antinuclear antibodies, including anti-DNA, anti-Smith (anti-Sm), and anti-ribonucleoprotein (anti-RNP) antibodies.

DNA is DNA, but disease can alter some of your DNA so these tests help to pinpoint any changes. Here's another section you might find interesting.

Anti-DNA antibodies

Hope this helps! It's all very interesting, but extremely confusing. blink.gif
Big Hugs,


Janey Willis
ISN Support Specialist
(Retired) ISN Assistant Webmaster
(Retired) ISN News Director
(Retired) ISN Technical Writer for Training Manuals
International Scleroderma Network (ISN)