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Biomarker for Diffuse Scleroderma skin has been discovered!


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#1 marys

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Posted 02 February 2008 - 11:36 AM

Hi my name is Mary and I've been diagnosis's with MCTD since 2001.I was wondering if someone can explain these results to me:this is from my 1st test
ESR 42H
ANTINUCLEAR AB SCR withRFX IFA *POSITIVE
RHEUM FACTOR 48H
ANA TITER 1:640
ANA PATTERN SPECKLED*
SED RATE 25H
SS-A AB 4.19H

2nd test:
ANA POSTIVE
ANTI-DS DNA *NEGATIVE
CYCLIC CITRULLINATED PEPTIDE AB IGG *12
RIBONUCLEOPROTEIN AB *124
SMITH AB *14

What does the * stand for?I sure hope someone can explain some of it.I know for sure I have the CRT in CREST and Lupus but not sure about Sjorgen's or Scleroderma.I saw a dermatologist because I"ve noticed whites spots on my thigh and forearms so she did a skin biopsy she said it could be Scleroderma does anyone else have these symptoms?
Sorry for rattling on but I really would like to know.

Hope everyone is feeling ok,
Mary

#2 janey

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Posted 02 February 2008 - 05:30 PM

Mary,
First I'd like to welcome you to the ISN Forums! You mention that you see a dermatologist. Are you also seeing a rheumatologist? Those are the doctors that specialize in autoimmune disorders of which MCTD is included.

I searched some of the links on this site (specifically the antibodies page) and have a few answers. Please know that I am not a doctor nor even trained in the medical field, so please verify all test results with your doctor. To me, it appears that tour tests are general diagnostic tests. Here's what I found:

ANA is associated with clinical condition such as systemic lupus erythematosus (SLE) (95%), drug induced lupus (90%), mixed connective tissue (95%), Sjogren's syndrome (80%), scleroderma (90%) and polymyositis/dermatomyositis (40%). [Up to Date Patient Information] The higher the "titer" the more likely there is an associated disease present. 1:40 or less is considered "negative" (low titer).

ANA pattern speckled could indicate SLE, Sjogren's syndrome, or chronic active hepatitis

ESR (SED rate) and CRP measure the degree of inflammation in the body. They don't point to any significant disease, but indicate disease activity (when high, inflammation is high)
ESR normal: 0 -15 males, 0 -20 females
CRP Low risk: <1mg/L
High risk: >3mg/L

The rheumatoid factor (RF) and CCP tests are primarily used to help diagnose rheumatoid arthritis (RA) and to distinguish it from other forms of arthritis and other conditions that cause similar symptoms of joint pain, inflammation, and stiffness.

Please keep in mind that "Positive test results" may also be seen in healthy patients and that goes for all of these tests.

I don't know what the "*" means, but any number followed by "H" indicates "high".

That's all I could find. One more thing. You mentioned that you have CREST. CREST is a type of systemic scleroderma. So it sounds like your MCTD is an overlap of lupus and scleroderma (CREST). I also have MCTD, but mine is scleroderma and polymyositis.

I hope this information was helpful. Please verify with your doctor.

Again welcome. We look forward to hearing more about you. There are lots of great people here for support and information. We're all glad you've join us.

Big Hugs,


Janey Willis
ISN Support Specialist
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International Scleroderma Network (ISN)

#3 marys

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Posted 03 February 2008 - 04:39 AM

Janey,

Thank you responding and for the welcoming. I've been reading the message board for a couple of weeks now and everyone is so nice and caring and alot of information which is geat.
Can I ask how long you have had the disease.How are you feeling health wise is it controllable with meds. some days the meds. just don't help either and you just want to stay in bed.I do take quite a few meds. a day and they just don't help especially in the winter time brrr.
Do you know with the test results what does SS-A AB,Smith AB is that Sjorgen's,and do you know what the CCPeptide is?I won't ask again just curios.I've seen a Rheumatologist for 4 years now.

Thanks again,
Mary

#4 aniwallar

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Posted 03 February 2008 - 04:33 PM

Janey:

What are the symptoms or test for polymyositis? I read about it and ask the doctor for test. She tell me that I had a test done when I went to the ER for heart pain. I don't know if it is the CPK test. The thing is, I have not been tested for polymyositis.
Thanks
Ani

#5 janey

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Posted 03 February 2008 - 06:18 PM

Mary,
I was diagnosed with MCTD in August 2003, but my symptoms came on fast and furious starting October 2002. The whole fatigue thing was really bad that first year, but once I start meds, the bricks holding me down suddenly just fell off one day. I haven't had that feeling in a very long time, but I do get tired quicker and have very little stamina and even less strength. I do believe the meds I've taken on the past 4.5 years have been quite helpful, with a couple of exceptions. I work very closely with my doctors about the medications because there are so many stories of overmedicating and that can do as much harm, if not more than the disease. My disease is mostly under control with the meds, but I still have a heart-lung situation going on that still needs to stabalize. This is the first year that I have not been diagnosed with another complication so we've been able to concentrate and my existing condition. My overall health you ask? I wish it were better, but know if could be A LOT WORSE, so I'm thankful for what I have. I'm still able to get out and about (with my oxygen bottle) and run errands, but my hiking days or over. Now we go to beaches in warm places. I'm NOT complaining about that.

I take another look and see if I can find the meaning of the other blood test. Most of those are new to me.

Ani,
My poly was originally diagnosed with the CPK (CK) blood test and then confirmed with a muscle biopsy. The primary symptom is muscle weakness especially in your arms, shoulder and legs. It became hard to get in and out of chairs and to wash my own hair. Eventually, I wasn't able to lift my head off the pillow without a little pull.

Hope this all helps.

Big Hugs to you both,
Janey Willis
ISN Support Specialist
(Retired) ISN Assistant Webmaster
(Retired) ISN News Director
(Retired) ISN Technical Writer for Training Manuals
International Scleroderma Network (ISN)

#6 Sweet

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Posted 04 February 2008 - 11:26 AM

Hi Mary,

Welcome to the Sclero Forums. Looks like you've already been given great advice, so I will make this a warm welcome instead of advice.

Look forward to knowing you better.
Warm and gentle hugs,

Pamela
ISN Support Specialist
International Scleroderma Network (ISN)