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Folic Acid May Undermine Methotrexate Efficacy


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#1 janey

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Posted 21 February 2008 - 05:52 PM

Folic Acid May Undermine Methotrexate Efficacy.

Folic acid supplementation can decrease the risk of adverse events associated with low-dose methotrexate treatment in patients with rheumatoid arthritis, but it also can decrease the efficacy of the methotrexate therapy and delay the drug's clinical efficacy. Rheumatology News. Vol 7, Issue 2, P5 (Feb 2008) (Also see: Medications and RA)

This item was posted in the ISN Newsroom. Check the Newsroom every day for the latest scleroderma medical and support information.


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#2 debonair susie

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Posted 22 February 2008 - 07:10 AM

Hmmmmmmmmmm... I used MTX for 13 years and later implemented the folic acid to help withthe nausea... Isn't another reason to take folic acid when using MTX as treatment... to replace the folic acid that's depleted from the body BECAUSE of the MTX?

I only quickly scanned this article, but this can't be good :blink:

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#3 Michelle2

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Posted 22 February 2008 - 11:38 AM

I have just recently prscribed this medicine. I just wanted to say thank you to the ones who suggested me to break up the pills thoughout the day. Boy, that made all the difference in the world. I am good as new. I feel great. My dr prescribed the folic acid and told me it was because it was depleted from the methotrexate. I have printed out this article and plan to bring it in with me on my next visit.

Thanks Janie for bringing this to our attention.
Take care and stay warm,

Michelle

#4 janey

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Posted 22 February 2008 - 01:58 PM

I took MTX for 3 years and folic acid every day without any problems (that I know of anyway). One thing to note from this study is that it pertains to "low-dose" methotrexate. It looks like part of the study, the mean dose was 8.1 mg/wk, then increased to 15 mg/wk. It would be interesting to know if folic acid reduces its affect at higher doses. I was on a 25 mg/wk injection for almost 3 years. The one thing my rheumatologist warned of was horrible mouth sores and that the folic acid would prevent them. I never got one, so I guess it worked.

Kuntrybumzz, I'm so glad that you are tolerating the MTX better now that you are breaking up your dosage. It's great to read "I am good as new. I feel great." Lovely words!

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#5 debonair susie

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Posted 24 February 2008 - 04:52 PM

I was on the "low dose" MTX... it was to treat my Psoriasis, which was out of hand for years and was the ONLY thing that worked to combat it.

I frequently had the sores in my mouth and certainly don't miss them, as I haven'tneeded MTX for 4 years, next month... I'm hapopy to say!

Hugs, Susie
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Susie Kraft
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