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Minocycline, Antibiotic

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#1 jefa


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Posted 07 April 2008 - 10:11 PM

From our Medical page on

Scleroderma Clinical Trials: Completed, Negative Results/Minocycline

Warning: Minocycline (doxicycline) treatment has been proven to be ineffective for the treatment of systemic scleroderma by reliable scientific study

Minocycline is not effective in systemic sclerosis: results of an open-label multicenter trial.The degree of change in the MRSS (modified Rodnan skin thickness score) was similar to that expected in the natural course of this disease. Based on these data, minocycline is not an effective therapy for SSc. PubMed. Arthritis rheumatologist. 2004 Feb;50(2):553-7.

Warm wishes,

Carrie Maddoux
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International Scleroderma Network (ISN)

#2 janey


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Posted 12 April 2008 - 09:08 AM

There have been several inquiries about minocycline lately due to an article in a magazine. Jefa posted this message last week so I thought I would bring it back up. There have been a couple of studies with scleroderma and minocycline. You can read about all the studies at the first link provided in Jefa's posting. In a nutshell,

Minocycline (doxicycline) treatment has been proven to be ineffective for the treatment of systemic scleroderma by reliable scientific study.

I know we are all looking for that miracle drug, but apparently this isn't it.

Big Hugs,
Janey Willis
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International Scleroderma Network (ISN)

#3 Snowbird


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Posted 12 April 2008 - 09:39 AM

Thanks for the update Jefa and Janey!

Sending good wishes your way!

#4 Guest_SADIE_*

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Posted 12 April 2008 - 10:19 AM

Thank you so much for the info!

#5 bmw


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Posted 12 April 2008 - 01:50 PM

Thanks for the info. I guess we're all just looking and hoping for a breakthrough. Birdman

#6 Shelley Ensz

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Posted 24 June 2008 - 06:58 AM

Just a reminder on this topic.
Warm Hugs,

Shelley Ensz
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#7 Lucy


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Posted 24 June 2008 - 10:56 AM

I tried minocycline when I was first sick. My SD continued to progress and progress rapidly. The minocycline did nothing but disturb my stomach.
Diffused Scleroderma
Diagnosed Dec/06
First Sympton Nov/05