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Biomarker for Diffuse Scleroderma skin has been discovered!


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Surgery and sclero


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#1 aka79

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Posted 23 November 2008 - 02:53 PM

Hi everybody. I want to thank everyone for their good wishes regarding my surgery for endometriosis. I had surgery on Thursday, spent the night a the hospital and I'm recovering really fast. The surgery was a success and they were able to remove all of the endometriosis and adhesions I had.

I have a question for those of you who have had surgery. My doctor mentioned that I had developed keloids from my previous surgery a couple of months ago. I've never had this before and was wondering if it could be related to sclero.

This doctor doesn't know much about sclero but he mentioned that the removal of endometriosis could help with my immune function. Some doctors believe endometriosis could be a trigger for autoimmunity in predisposed women, so this makes sense. I am holding on to to the hope that my body will stabilize after the surgery.

Love to all,
Ana

#2 Sheryl

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Posted 23 November 2008 - 03:09 PM

Ana, I heal with Keloid scarring. I had my gall bladder removed at 28 and that is when I didn't heal properly. Huge thick scar. All my scars are thick and ugly. I wasn't diagnosed with Scleroderma until I was 49. Though I had several surgeries over the years preceding sclero.
Strength and Warmth,
Sheryl

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#3 Sweet

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Posted 25 November 2008 - 06:09 AM

Hi Ana,

This is very interesting to me. I had a total hysterectomy 13 years ago for endometriosis and adenomiosis. It would have been about 5 years after that I was diagnosed with CREST. I had never heard about the connection before.

I had a melanoma removed from the back of my leg a couple of years ago and it healed just fine. I've had several surgeries prior to being diagnosed with sclero and healed nicely.

There may be a correlation, but some people are just more prone to keloids than others and it isn't necessarily from sclero.
Warm and gentle hugs,

Pamela
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International Scleroderma Network (ISN)

#4 shennen0820

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Posted 25 November 2008 - 08:42 AM

Glad to hear that everything went well for you...
Shennen

#5 Shelley Ensz

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Posted 26 November 2008 - 03:33 AM

Hi Ana,

I'm sorry that you also have endometriosis, but glad that your surgery went well. We have a section on it at Autoimmune Diseases: Endometriosis. An article we have listed there is:

Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease? Recently, endometriosis has also been considered to be an autoimmune disease, owing to the presence of autoantibodies, the association with other autoimmune diseases and recurrent immune-mediated abortion. These findings are in apparent contradiction with the reduced cell-mediated natural immunity observed during the disease. PubMed. Trends Mol Med 2003 May;9(5):223-228.

There is also such a thing as Keloidal Scleroderma. As we explain there,

"Sometimes keloids occur in patients who have scleroderma, and in particular they are more likely to occur in patients with systemic scleroderma. The terms "keloidal" or "nodular" scleroderma are used interchangeably. (See: What is Scleroderma?)

"In one study, keloidal or nodular scleroderma occurred in 6 out of 45 patients with systemic scleroderma. All of the patients with keloidal or nodular scleroderma also had systemic scleroderma, so the presence of keloids in a patient with symptoms of scleroderma should alert the physician to the possibility of systemic scleroderma (not just morphea, as the term "keloid morphea" seems to imply.)"
Warm Hugs,

Shelley Ensz
Founder and President
International Scleroderma Network (ISN)
Hotline and Donations: 1-800-564-7099

The most important thing in the world to know about scleroderma is sclero.org.

#6 smac0719

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Posted 27 November 2008 - 03:09 PM

Interesting conversation. I too suffered with endometriosis and had a hysterectomy 8 years ago due to problems with uterine fibroids. I also have PCOS (polycystic ovary syndrome) which I have been told is autoimmune related too. I have also been diagnosed with keloidal sclero. About 10 years ago, my scars from injury or surgery started healing with keloids. It makes me wonder how all of this is related.
I may have Scleroderma, but Scleroderma doesn't have me!

#7 debonair susie

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Posted 29 November 2008 - 09:14 AM

WOW!!!

Am I ever glad I've come here today! I'm finding out about some things of great interest :D

Smac, I also have had PCOS. I HOPE that it is something that doesn't become more of an issue withmy being near post-menopausal :unsure:

In regard to keloids...would this be a reason why my doctors don't want me to have elective surgeries (which I wouldn't consider anyway)?

Hugs,
Susie
Special Hugs,

Susie Kraft
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#8 Sharonvandee

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Posted 30 November 2008 - 10:08 PM

I have read a lot of article that connect endometriosis and PCOS to auto immune issues. I have had PCOS for 15 years and was diagnosed with endometriosis 9 years ago. I had a hysterectomy 3 years ago for endometriosis issues. Even that has not gotten rid of the disease as they have now found endo in other parts of my body. Last year I was diagnosed with mixed connective tissue disease and now scleroderma CREsT.

So I definitely think these conditions are all inter related
Kindest Regards

Sharon

Diagnosis Scleroderma-crest, Scolliosis, Asthma, ILD, Plueral Fibrosis, GERD, Hiatus hernia, Anticardiolipin positive, ANA positive

a little bent and broken and almost beyond repair!

#9 Buttons

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Posted 30 November 2008 - 11:35 PM

This is certainly an interesting read. I had a total hysterectomy 16 years ago due to endometriosis after this I began having all sorts of weird problems along with Raynaud's starting. I did not realise that endometriosis is thought to be autoimmune related.

Jensue

#10 mom has sys scleroderma

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Posted 11 December 2008 - 05:22 AM

I am starting to see a pattern forming with endometriosis, hysterectomy, and CREST or sclero. My mother had endometriosis after 2 children in her early 40's, had a hysterectomy. She got breast cancer in her 50s and then I think she was diagnosed with Raynaud's and sclero. Then she was diagnosed with the esophageal part - hiatal hernia, couldn't keep things down so she had her esophagus scoped and scraped a couple of times. At age 77 she had her gall bladder removed, then was diagnosed with colon cancer. She was operated on but the systemic scleroderma took it's toll on her. She never got better enough to go through chemo and radiation. Her heart, lungs and kidneys shut down after the surgery. She died 4 weeks later. Interesting pattern...

#11 Peggy

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Posted 11 December 2008 - 06:27 AM

I also had this and a partial hysterectomy in my early 30's. I too had no idea that this is another autoimmune. Now having 6 ongoing autoimmune diseases and knowing that this is one too is unbelievable.
I am always learning on this site!

Warm hugs,

Peggy

#12 Sheryl

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Posted 11 December 2008 - 12:37 PM

Mom has sys, thank you for joining us in the ISN forums. I am sorry you lost your mother to Scleroderma. This time of year is hard on everyone that has lost family members for any reason. I am sure you know many things that may have helped your mother along the way with her disease. We need the knowledge from others that have gone through certain process' of this disease or any of the auto immune disease's. Do you have any signs or symptoms of auto immune diseases at this time?
Strength and Warmth,
Sheryl

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#13 Shelley Ensz

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Posted 11 December 2008 - 02:33 PM

Dear Mom has sys,

Welcome to Sclero Forums. I'm very sorry your mother had scleroderma, and that she has passed away. I'm sure you'll bring a lot of understanding and insight here as to what caregivers go through.
Warm Hugs,

Shelley Ensz
Founder and President
International Scleroderma Network (ISN)
Hotline and Donations: 1-800-564-7099

The most important thing in the world to know about scleroderma is sclero.org.