My daughter who has scleroderma since 4 years has painful ulcers over the joints, which don't heal for months together. Because of that she has difficulty in walking and great difficulty in doing physiotherapy. Can anybody help me? Is there any role for cyclophosphamide infusion in healing the ulcer?
Ulcers over the joints
Posted 26 January 2009 - 01:54 AM
Posted 26 January 2009 - 05:16 AM
I'm sorry your daughter is having such problems. How old is she?
You don't say which joints are affected by the ulcers nor how they are treating them. Most treatment seems to involve treating any infection at the site of the ulcer, protecting the area from contamination and any further damage. As you already know, ulcers can take a long time to heal.
I'm not a doctor, but I have never read of Cytoxan in any form being used to treat ulcers. If you click on the highlighted word, it will take you to the page we have on it.
Cytoxan was developed to treat cancer, but has since been used as an extremely powerful immune system suppressant. It has many potentially harmful side effects. Has your daughter's doctor suggested using this?
Hope this information helps.
Best wishes to you and to her,
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Posted 26 January 2009 - 06:34 AM
Posted 26 January 2009 - 08:59 PM
Mary in Texas
Posted 27 January 2009 - 03:51 PM
Posted 27 January 2009 - 04:06 PM
You are correct, Viagra is an impotency drug. However, it achieves this by stimulating a great improvement in circulation, so it has been found very useful for treating scleroderma digital ulcers. So it's one of the very few scleroderma treatments that is more often welcomed than shunned.
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Posted 28 January 2009 - 06:38 AM
I to suffer with finger tip ulcers and have tried all the meds including viagra. I choose to discontinue the viagra and I believe it was what caused me to have 'break through bleeding'...I am post menopausal. What about Gabapentin? Have you given that a try? I had to take mine as a compound cream since I did not care to take it orally.
Hope this helps.
Posted 28 January 2009 - 11:07 AM
As a matter of fact, my dr wanted to prescribe it for my raynauds issues (I do not suffer from finger ulcers, thankfully). However, I opted not to take it and am taking another medication that works well for me.
Posted 29 January 2009 - 09:43 PM
Diagnosed 2006 - Diffuse Scleroderma
Skin and lung involvement
Posted 30 January 2009 - 08:23 AM
Sorry to hear about your daughters ulcers, vasodilators like norvasc helped my Raynauds, also viagra can help with circulation and nitro paste applied topically around the ulcers can aid in helping circulation to the affected areas. Pulmonary hypertensive meds like Bosantan and Leitaris have been shown to aid not only pulmonary hypertension but aid secondary digital ulceration healing. I was on Leitaris for my pulmonary hypertension and with the other meds my ulcers improved. I also had IV cyclophosphamide over six months once monthly it somewhat helped soften my skin and stopped my lungs from deteriorating for awhile.