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Antibodies against PM/Scl-75 and PM/Scl-100


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#1 Jeannie McClelland

Jeannie McClelland

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Posted 24 February 2009 - 02:46 AM

Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms. They are mainly directed to the PM/Scl-75 antigen. Consequently, the detection of anti-PM/Scl antibodies by tests based only on PM/Scl-100 as antigen source may miss a relevant number of SSc patients positive for these antibodies. K. Hanke. Arthritis Research & Therapy 2009, 11:R22. (Also see: Autoantibodies in Scleroderma)

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