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Does methotrexate change your mood?


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19 replies to this topic

#1 Amanda Thorpe

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Posted 11 June 2009 - 05:24 AM

Hello All

I am hoping those of you with experience of methotrexate can give me some advice.

I took my first dose 2 days ago and take the folic acid tonight. My question is can it make you feel really sad? I have been extra tired since taking it but today feel really sad and wondered if it's the methotrexate? I am not usually a sad person and it doesn't feel hormonal and there's nothing else going on, it's really strange.

I know it can cause mood changes but could it do it after one dose?

Any ideas greatly appreciated.

Take care.
Amanda Thorpe
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#2 lizzie

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Posted 11 June 2009 - 07:22 AM

Hi Amanda, I was interestd to see your question as I have just been wondering the same thing. I have so far had 3 doses of methotrexate (so obviously far more experienced than you in these matters!) and have remarked to my husband that it seems to make me irritable in the 24 hours after injecting it. He didn't disagree!

Lizzie

#3 janey

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Posted 11 June 2009 - 08:39 AM

Amanda,
I was on methotrexate for 3 years and I don't remember it making me sad. In fact, because it helped to greatly decrease my fatigue, I felt much better emotionally. I think we all get sad days once in a while. I call them my cloudy days. They are occurring less and less frequently, but I think we're entitled.

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#4 Amanda Thorpe

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Posted 11 June 2009 - 10:22 AM

Hello Lizzie,

Your husband didn't disagree, well I never. I did wonder if it would make me irritable though so maybe I've got that to come then my husband will be the one sad! :lol:

Hello Janey,

Cloudy days, love it. I am hoping it will help with the fatigue as it's unbearable at the moment. Mind you that's not been helped by the fact that I have not been on an immunosuppressant for about 3 months now so am having one mighty long flare!
Amanda Thorpe
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#5 smac0719

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Posted 11 June 2009 - 10:28 AM

I have been on methotrexate for a couple of years now, increasing from 10mg to 25mg. I have not found that it altered my mood. Although initially I felt a little more "beat down" within the first 24-48 hours of taking it, but after a few months I didn't have that feeling anymore either.
I may have Scleroderma, but Scleroderma doesn't have me!

#6 Helen

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Posted 11 June 2009 - 09:26 PM

Hi Amanda

I have been on 25mg Methotrexate for a couple of years and haven't felt any side effects. I feel much better since I have been on it.

Helen

#7 Amanda Thorpe

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Posted 12 June 2009 - 05:45 AM

Hello Smac,

Thanks for your reply, I can relate to the "beat down" feeling not long after the first dose.

Hello Helen

I am also hoping for no side effects and looking forward to feeling better, actually today I do!

Take care.
Amanda Thorpe
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#8 Shelley Ensz

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Posted 12 June 2009 - 06:21 AM

Hi Amanda,

As I understand it, moodiness can be a side effect of Methotrexate, so you should report it to your doctor. Maybe it's just a passing thing, perhaps even some understandable upset about having to go on another drug or frustration with the flare or progression lasting so long. But, maybe it's due to the Methotrexate, too. Either way it's something you want to keep an eye on.

Also try to avoid making yourself feel bad for feeling bad, if you can. I preach so much about positive attitude that I'm very apt to even come down on myself when I'm having a bad day or working through stress or negative reactions, which only makes things worse! So I've found it is not very helpful for me to feel bad for feeling bad just because I don't usually feel (emotionally) bad. :blink:
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#9 Amanda Thorpe

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Posted 13 June 2009 - 09:44 AM

Hello Shelley

You have such a way with words and you're right about feeling bad for feeling bad.

Methotrexate moodiness is being monitored by my husband! :rolleyes:

Take care.
Amanda Thorpe
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#10 chockers

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Posted 13 June 2009 - 10:28 AM

Yes I felt like this very weird and wonderful but it's because you have not got used to it yet it takes a a while.
I speak on the NRAS (national rheumatoid arthritis society) fourm and its comom to feel like this for a while until the body is used to it. Loads of people are on it for rheumatoid arthritis.

I have taken it for 2 years now and at least 1 year 10 months I had no promlems, don't know I have had it. Also they say take it at night with a meal if gives you promlems.

Don't forget it takes 12 weeks to kick in then you will feel differance each week. For me its done wonders and you can inject it if it makes you feel sick.

christine

#11 chockers

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Posted 13 June 2009 - 10:31 AM

I think you will feel tons better in 3 months. I was weird and wonderful in the first months don't give up you are getting used to it.

christine

#12 Peggy

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Posted 13 June 2009 - 10:35 AM

I have just taken my 3rd dose and the only thing I've noticed is that my fatigue is even worse than it was before. I have also had some nausea but I haven't noticed any change in my mood. I take the oral dose so I take it on Monday morning so I have the week to deal with any side effects. What I have also noticed is that my muscle pain is better than it was before so this is a very positive thing for me as that has been so bad. The Cellcept is working on softening the skin and the methotrexate is working on the muscle pain............it's all good. Now once I'm done having the angiogram for the myocardial ischemia that's developed I'll be good to go!!

I hope your mood swings get better for you. I'm sure it's hard having down days and not being able to do anything about it being its from a medication.

Warm hugs,

Peggy

#13 ozzy69

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Posted 13 June 2009 - 01:52 PM

Hi Amanda,

I took it for three months. I did not have any good results so my doctor took me off of it. I would get more depressed because it made me feel so run down all week. I have felt better mood wise since I have been off the last month..

Hugs,
Nina

#14 chockers

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Posted 13 June 2009 - 10:12 PM

yes the triedness goes with being new to MTX it wll pass .
christine

#15 lizzie

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Posted 13 June 2009 - 10:32 PM

Hi again Amanda. As I said previously, I have so far had three doses of the methotrexate and have had little in the way of side effects other then the irritabiity. I was told that would be up to 12 weeks befroe I saw any effect. I have not noticed any difference in the scleroderma (am taking it due to skin changes), and in fact think I have more aches and pains than I did before. I have though already noticed a huge improvement in my psoriasis (which I have had mildly for some time), so obviously doing something. Will give it a few more weeks to see if also comes up trumps re the sclero and then decide if it is worth continuing.

Lizzie

#16 LookingUp1979

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Posted 17 August 2010 - 03:15 AM

I have started taking MTX and have been feeling much more sad than usual.
So I relate to you!
Not sure whether the MTX is actually affecting me by making me sad, or whether I'm just sad because my condition has made me have to stop work and take some time off.
You seen any improvements in your mood? Maybe it's just an initial effect? (i'm only starting week 3 of MTX today)
Hope you are feeling better.

#17 Amanda Thorpe

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Posted 18 August 2010 - 02:06 AM

Hello LookingUp

I hope that you are able to return to work soon and that the methotrexate helps your symptoms.

Take care and keep posting.
Amanda Thorpe
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#18 julien

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Posted 26 November 2010 - 05:57 AM

I have systemic scleroderma and took methotraxate for a year to monitor its effects. I felt I had only half a life. The bad days after the weekly dose, then feeling more or less normal for the other half of the week. In consultation with my doctors, I decided to take things into my own hands and for the last eight months have done a form of meditation for management of the pain. The difference has been remarkable. I know we can't advocate for what might be called 'alternative' therapies, but am I allowed to suggest that fellow sufferers look up 'mindfulness for pain relief'? Some people just can't deal with the idea of being dependent on chemicals for the rest of our lives. I would be really interested in replies to this post.

#19 Jeannie McClelland

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Posted 26 November 2010 - 06:43 AM

Hi Julien,

Were you being given methotrexate for pain or have I misunderstood? It, in itself, isn't a pain medication but is used to treat an underlying condition that may be the cause of pain.

Mindfulness and meditation - as it happens, we have several articles on these very subjects in our section on Managing Pain.

I too use meditation to better manage my pain levels. There are also those of us who can't tolerate most pain medications or for whom the side effects such as constipation, dry mouth, etc. worsen already bad situation and need to find another way to improve our quality of life. However, there does remain, I believe, a time and a place, for pharmacological intervention.

Best wishes,
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#20 Amanda Thorpe

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Posted 26 November 2010 - 10:11 AM

Hello Julien

I am on methotrexate as an immunosuppressant and am pleased to say the side effects have worn off. As far as pain relief it's a case of what works for you, for me I am happy to use conventional pill formed relief...ahhh...that's better! :VeryHappy:

Take care.
Amanda Thorpe
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