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#1 Lillskuzi


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Posted 24 June 2009 - 08:56 AM

Hello all

I have been wondering about domperidone, which I take to help move food through my stomach faster.
Do you know if it is something which only starts taking effect once you have been taking it on a regular basis for a while? So does it take a while to build up to being effective?

Or is it supposed to work just as well when you take it on an ad-hoc basis?

#2 Amanda Thorpe

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Posted 24 June 2009 - 09:33 AM

Hello Susie

I did not find domperidone (motillium) useful at all ever. Metaclopramide works better for me and I take it 3 times a day before food to make sure it doesn't dawdle it the esophagus all day! I'm fairly new to the gastro club so still getting used to the symptoms, reflux and food sitting where it shouldn't for hours on end so only have experience of a few medications.

I've no doubt one of the "heavy weights" will chime in with more info.

Take care.
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#3 Lillskuzi


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Posted 24 June 2009 - 11:43 PM

Thanks for your reply, Amanda.

I have to say, I don't think the gastro club is the best club I have ever belonged to! Certainly one I wouldn't have chosen to sign up for!!! But welcome, anyway ;-)

#4 Jeannie McClelland

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Posted 25 June 2009 - 02:31 AM

Hi Susie and Amanda,

I guess I classify as one of the 'heavy weights' in more ways (weighs?) than one! :lol:

I've been taking domperidone for a couple of years now, at the recommendation of my GI. I've had good success with it, more when I am compliant to his dosage/timing. I'm supposed to take it 1/2 hour before meals (he calls that 'loading' in preparation for the food to come) and at bedtime.

Before my full fundoplication I was taking the maximum dosage per day but since GERD is no longer an issue for me, I am able to take a lower dosage now. If I don't I get bloating and bowel issues, as my stomach and intestines are also affected.

It has a 7-hour half life (meaning one half of it is metabolized within 7 hours) so I would say (and you should check with your chemist) that just taking it as you would an antacid, say, would not be effective. One major plus, and the one that convinced my GI to recommend it over the other drugs used and available in the USA, is that it doesn't cross the blood brain barrier and therefore there is less risk of such nasty side effects of tardive dyskinesia (think Parkinson's tremor) and can be safely used in Parkinson's patients.

Hope that helps! Warm hugs,
Jeannie McClelland
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#5 Lillskuzi


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Posted 26 June 2009 - 10:08 AM

HI Jeannie

Thanks very much for your reply. That's interesting about the half life. I should talk to my pharmacist a bit.