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Systemic Sclerosis (Scleroderma) in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview of Polyautoimmunity
Scleroderma in Overlap
Connective Tissue Disease (CTD)
Mixed Connective Tissue Disease (MCTD)
Multiple Autoimmune Syndrome
Shared Autoimmunity
Undifferentiated Connective Tissue Disease (UCTD)
Overlap Patient and Caregiver Stories

Overview of Polyautoimmunity

Scleroderma, or scleroderma symptoms, can occur in overlap with other illnesses. (Also see: What is Scleroderma?, Types of Scleroderma and Systemic Symptoms)
Overlap connective tissue disease syndromes. Overlap Syndromes (OSs) have been defined as entities satisfying classification criteria of at least two connective tissue diseases (CTDs) occurring at the same or at different times in the same patient. Autoimmun Rev. 2012 Jun 26.
Introducing Polyautoimmunity: Secondary Autoimmune Diseases No Longer Exist. Polyautoimmunity is a term that can group all the taxonomy terms referring to coexistence of well-defined autoimmune diseases (ADs) in a single individual because some of the terms previously used are confusing and exclude various associations. NCBI. Autoimmune Dis. 2012; 2012: 254319. (Also see: Multiple Autoimmune Syndrome)
The Autoimmune Tautology: From Polyautoimmunity and Familial Autoimmunity to the Autoimmune Genes. Polyautoimmunity is the presence of two or more autoimmune diseases in a single patient while familial autoimmunity occurs when different relatives from a nuclear family present with diverse autoimmune diseases. Hindawi. Autoimmune Diseases Volume 2012, Article ID 297193.(Also see: Multiple Autoimmune Syndrome)

Scleroderma in Overlap

Scleroderma in Overlap. When Systemic Sclerosis (in either the Limited or the Diffuse form) appears in conjunction with features of one or more other connective tissue diseases (such as Systemic Lupus Erythematosus, Polymyositis, Dermatomyositis) it is called "overlap." ISN.
Disease progression in systemic sclerosis (SSc)-overlap syndrome is significantly different from limited (IcSSc) and diffuse cutaneous systemic sclerosis (dcSSc). SSc-overlap syndromes should be regarded as a separate SSc subset, distinct from lcSSc and dcSSc, due to a different progression of the disease, different proportional distribution of specific autoantibodies, and of different organ involvement. PubMed, Ann Rheum Dis, 2014 Jan 3.
Clinical and Serological Hallmarks of Systemic Sclerosis Overlap Syndromes. About one-fifth of SSc cases had overlap features. There were distinct serological features that may predict specific clinical presentation and disease course. Angela Pakozdi, J Rheumatol. 101248 2011 Aug 15.
Scleroderma Overlap Syndrome. The definition of scleroderma overlap syndrome is important, especially in patients who need high dose corticosteroids for complications of a connective tissue disease (CTD). The use of novel biological therapies may be advocated in these patients to avoid the hazardous influences of high-dose steroids, especially renal crisis. Alexandra Balbir-Gurman MD, (PubMed) Isr Med Assoc J. 2011 Jan;13(1):14-20. (Also see: Medications)
Lupus and Scleroderma Differences and Similarities. Some patients may be told they have lupus by one doctor, only for another consultant to state they have a scleroderma related disorder. How could this be the case? Daniel J. Wallace M.D. Lupus International. 2011. (Also see: Lupus)

Connective Tissue Disease (CTD)

Connective Tissue Disease (CTD). Connective tissue diseases include systemic lupus erythematosus, rheumatoid arthritis, scleroderma, polymyositis, and dermatomyositis. ISN.

Mixed Connective Tissue Disease (MCTD)

Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. ISN.

Multiple Autoimmune Syndrome (MAS)

Multiple Autoimmune Syndrome (MAS) is the coexistence of three or more autoimmune diseases. At least one of them is usually a skin disease, such as psoriasis or scleroderma. ISN.

Undifferentiated Connective Tissue Disease (UCTD)

Undifferentiated Connective Tissue Disease (UCTD). When a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called Undifferentiated Connective Tissue Disease. ISN.

Shared Autoimmunity

Shared Autoimmunity is a rather loose term. It variously refers to autoantibodies, symptoms, or presence of autoimmune diseases within the same patient or within several or more members of the same family. ISN.

Overlap Patient & Caregiver Stories

Andi P: UCTD and Possible Scleroderma It is believed that I do have an autoimmune disease they are not sure if it is systemic or not, but I know what I live through on a daily basis...
Angela S: Overlap Syndrome I am twenty-five years old and I was diagnosed with polymyositis and scleroderma, rheumatoid arthritis, mitral valve prolapse, a heart murmur, and pericarditis...
Annette G: MCTD, Systemic Scleroderma, Chronic Kidney Disease, CFS, Fibromyalgia, Trigeminal Neuralgia, TMJ People think that because I am a nurse I have all the answers. Well guess what? I don't...
More Overlap Patient and Caregiver Story Listings...
 
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