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Systemic Sclerosis: Scleroderma in Overlap, MCTD, UCTD
Overview of Polyautoimmunity
Scleroderma in Overlap
Connective Tissue Disease (CTD)
Mixed Connective Tissue Disease (MCTD)
Multiple Autoimmune Syndrome
Shared Autoimmunity
Undifferentiated Connective Tissue Disease (UCTD)
Overlap Patient and Caregiver Stories

Mixed Connective Tissue Disease (MCTD)

Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. (Also see: Lupus, Systemic Sclerosis, Polymyositis, and Antibodies)
MCTD May Be Subset of Systemic Scleroderma. Many patients with mixed connective tissue disease may represent a subset of systemic scleroderma, rather than a disease involving overlapping connective tissue disorders as is commonly believed, or a subset of lupus as some have suggested over the years, Dr. Virginia Steen said at the Congress of Clinical Rheumatology. Rheumatology News. 06/05/12. (Also see: Dr. Virginia Steen)
Mixed Connective Tissue Disease eMedicine Journal.
Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration. Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. (Springerlink) Giorgio Tasca. Neurological Sciences, 2 October 2010. (Also see: Myopathy)
Clinical study of interstitial lung disease (ILD) in mixed connective tissue disease (MCTD). When systemic sclerosis manifestations are present, MCTD-ILD seems to associate more frequently pulmonary hypertension and progressive ILD. G. Colin . Revue des Maladies Respiratoires 2010 March. (Also see: Pulmonary Fibrosis)
Sensorineural hearing loss as a common manifestation in patients with mixed connective tissue disease. Raynaud’s phenomenon, antiphospholipid and antiendothelial cell antibodies, increased serum levels of proinflammatory cytokines and a reduced number of regulatory T cells were found to be associated with sensorineural hearing loss in mixed connective tissue disease patients. International Journal of Clinical Rheumatology, Dec 2010, Vol. 5, No. 6, Pages 605-607.
Digital (Finger) Ulcer from Mixed Connective Tissue Disease (MCTD). This digital ulcer is 14 weeks old. It was caused by secondary Raynaud's phenomenon, in a patient with Mixed Connective Tissue Disease (MCTD). The MCTD was diagnosed 5 years ago, after thyroid gland removal. ISN Photo Repository, contributed by Jeanne N.
 
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