| Systemic Sclerosis: Scleroderma in Overlap, MCTD, UCTD |
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Mixed Connective Tissue Disease (MCTD) |
| Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. (Also see: Lupus, Systemic Sclerosis, Polymyositis, and Antibodies) |
| Mixed Connective Tissue Disease eMedicine Journal. |
| Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration. Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. (Springerlink) Giorgio Tasca. Neurological Sciences, 2 October 2010. (Also see: Myopathy) |
| Clinical study of interstitial lung disease (ILD) in mixed connective tissue disease (MCTD). MCTD is characterized by a combination of clinical features of progressive systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, polymyositis/dermatomyositis, with a high anti-snRNP antibody titer. MCTD-ILD characteristics are not specific. When systemic sclerosis manifestations are present, MCTD-ILD seems to associate more frequently pulmonary hypertension and progressive ILD. G. Colin . Revue des Maladies Respiratoires 2010 March. (Also see: Pulmonary Fibrosis) |
| Fifteen-year experience of pediatric-onset mixed connective tissue disease (MCTD). The aim of this study was to investigate the initial clinical manifestations, laboratory data, complications, and outcomes of patients with pediatric-onset MCTD in Taiwan. The most common symptoms at disease onset were polyarthritis and Raynaud's phenomenon. Sclerodermatous changes of internal organs were a poor prognostic factor in our population. The clinical symptoms changed with time, and other symptoms encompassing the criteria for MCTD developed sequentially. (SpringerLink) Y. Tsai. Clinical Rheumatology. September 16 2009. |
| Sensorineural Hearing Loss (SNHL) in Patients with Mixed Connective Tissue Disease (MCTD): Immunological Markers and Cytokine Levels. In MCTD, SNHL is a specific organ manifestation and appears frequently. A. Hajas. JRheum. August 14, 2009. |
| Efficacy of bosentan in the treatment of a patient with mixed connective tissue disease (MCTD) complicated by pulmonary arterial hypertension (PAH). This study aimed to investigate the efficacy of bosentan in the treatment of severe PAH in a young female patient with MCTD associated with antiphospholipid syndrome. Indeed, the patient very likely improved secondary to the effect of bosentan. (SpringerLink) C. Naclerio.Clinical Rheumatology. August 4 2009. |
| Erosive or Deforming Arthritis in Systemic Lupus Erithematosus: Jaccoud's Arthritis, Overlap Syndromes or Mixed Connective Tissue Disease? In our experience, erosive or deforming arthritis is rare in SLE patients who do not meet criteria for MCTD or Overlap Syndromes. The so-called Jaccoud's arthritis is the most frequent deforming arthritis among them. E. Becerra. (THU0268) EULAR 2009. (Also see: Lupus) |
| Maternal
Mixed Connective Tissue Disease and Offspring with Chondrodysplasia Punctata
(CDP). Review
of previously published cases of CDP associated with autoimmune disease
suggests that placental crossing of maternal autoantibodies during pregnancy
specifically affecting the normal development of fetal growth plates is
responsible for CDP in the offspring in these cases. PubMed) SW
Schulz. Semin Arthrits Rheum. Dec 23 2008. (Also see: Causes of Scleroderma) |
| Clinical and Immunologic Manifestations of Mixed Connective Tissue Disease (MTCD) in a Miami Population Compared to a Midwestern US Caucasian Population. The Miami and Missouri Caucasian MCTD groups were largely similar; however, gastroesophageal reflux, sclerodactyly, and malar rash were significantly more frequent in the Missouri MCTD group and alopecia was more frequent in the Miami MCTD group. J Rheumatol 2008;35:429-37 |
| Evaluation of Paraoxonase Activity in Patients with Mixed Connective Tissue Disease (MCTD). Our results indicate that in patients with MCTD there is an increased risk for atherosclerosis. J Rheumatol 2008;35:237-43. (Also see: Cardiac) (Note: The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body.) |
| The Cutoff Points of Antinuclear Antibody (ANA) with High Negative and Positive Predictive Values. Analysis of 5655 Cases. The cutoff point of ANA titer 160 is appropriate to exclude SLE (Lupus), MCTD (Mixed Connective Tissue Disease), SSc (Systemic Scleroderma) in most of the clinical setting. ANA 640 or higher deserves further investigation such as disease specific autoantibodies even without characteristic clinical findings, especially after proper exams for chronic liver and thyroid diseases and RA (Rheumatoid Arthritis). Hisanori Shimizu. 1515/129. ACR 2007. (Also see:SSc Antibodies, Lupus, and RA) |
| Digital (Finger) Ulcer from Mixed Connective Tissue Disease (MCTD). This digital ulcer is 14 weeks old. It was caused by secondary Raynaud's phenomenon, in a patient with Mixed Connective Tissue Disease (MCTD). The MCTD was diagnosed 5 years ago, after thyroid gland removal. ISN Photo Repository, contributed by Jeanne N. |
