Multiple Autoimmune Syndrome (MAS)

Multiple Autoimmune Syndrome (MAS) is the coexistence of three or more autoimmune diseases. At least one of them is usually a skin disease, such as psoriasis or scleroderma.

Associated Autoimmune Diseases (AID) in Systemic Sclerosis (SSc) Define a Subset of Patients with Milder Disease: Results from Two Large Cohorts of European Caucasian Patients. Our study shows that about a quarter of this large series of European Caucasian patients affected by SSc has developed one or more AID known to occur with connective tissue diseases. J. Avouac. (FRI0324) EULAR 2009.

Multiple Autoimmune Syndrome (Three or More Co-existing Autoimmune Diseases). Multiple autoimmune syndrome (MAS) is a condition in which patients have at least three distinct autoimmune conditions. In multiple autoimmune syndrome, patients often have at least one dermatological condition. Suite 101.

Coexistence of five autoimmune diseases: diagnostic and therapeutic difficulties. The literature reports overlap syndromes in various combinations; however, the coexistence of five autoimmune diseases is extremely rare. (PubMed) Wielosz E. Rheumatol Int. 2008 July.

Multiple Autoimmune Disease Genetics Consortium. MADGC is a group of leading genetic researchers who have joined efforts to identify and understand the genes that autoimmune diseases have in common. MADGC.

Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes. At least two of nine “core” autoimmune diseases are present in each of these families. These core diseases include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), multiple sclerosis (MS), autoimmune thyroid disease (Hashimoto thyroiditis or Graves disease), juvenile RA, inflammatory bowel disease (Crohn disease or ulcerative colitis), psoriasis, and primary Sjögren syndrome. Am J Hum Genet. 2005 April; 76(4): 561–571.

Multiple autoimmune syndrome. Reynolds-syndrome (acral scleroderma, primary biliary cirrhosis, Sjogren syndrome) associated with the lupus erythematosus/lichen planus overlap syndrome. Hautarzt. 2004 May;55(5):465-70.