| Systemic Sclerosis: Scleroderma in Overlap, MCTD, UCTD |
| This page was written by Shelley Ensz and has not yet been medically edited. See Disclaimer. |
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| Scleroderma in Overlap |
| When Systemic Sclerosis (in either the Limited or the Diffuse form) appears in conjunction with features of one or more other connective tissue diseases (such as Systemic Lupus Erythematosus, Polymyositis, Dermatomyositis) it is called "overlap." (Also see: What is Scleroderma?) |
| Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases? A Case Report. The coexistence of features of chronic cutaneous lupus erythematosus and scleroderma in the same skin lesions is very infrequent and has only been reported in 3 patients. (ScienceDirect) Journal of the American Academy of Dermatology Vol 58, Issue 4, April 2008, Pp 665-667. (Also see: Lupus) |
| Systemic Sclerosis and Systemic Lupus Erythematosus have Distinct Gene Expression Profiles in the Peripheral Blood Cells. These data show that a limited number of genes reliably distinguished SSc from SLE. Shervin Assassi. 38/38. ACR 2007. (Also see: Lupus) |
| Anticentromere Antibodies (ACA) Identify Patients with Sjögren's Syndrome (SS) and Autoimmune Overlap Syndrome. The presence of ACA among patients with SS allows identification of a subset of patients with "SS overlap syndrome," who show a wide diversity of autoimmunity, encompassing but not limited to limited cutaneous sclerosis (SSc). J Rheumatol 2007;34:2253-8 (Also see: Sjogren's Syndrome and Antibodies) |
| Polyautoimmunity In Patients With Systemic Sclerosis(SSc). Polyautoimmunity is frequent in patients with SSc, and autoimmune diseases cluster within families of these patients. A. Rojas-Villarraga THU0314 EULAR 2007. (Also see: Autoimmunity) |
| Multiple sclerosis associated with systemic sclerosis. Multiple sclerosis (MS) has been increasingly reported in association with other autoimmune diseases not primary affected the nervous system. We report here the case of a 46-year-old female patient with longstanding MS since the age of 26, who developed SSc 12 years later. IngentaConnect. Rheumatology International, Vol 27, No 8, June 2007, pp. 771-773(3). (Also see: Multiple Sclerosis) |
| Proliferative vascular retinopathy in polymyositis and dermatomyositis with scleroderma (overlap syndrome). Retinal vascular occlusion with development of proliferative changes can occur in polymyositis/dermatomyositis. PubMed. Ocul Immunol Inflamm. 2007 Jan-Feb;15(1):45-9. (Also see: Polymyositis/Dermatomyositis, and Eye Involvement) |
| Coexistence of systemic sclerosis with other autoimmune diseases. Our study shows that approximately one third of patients affected by systemic sclerosis developed one or more additional autoimmune diseases. Therefore patients with systemic sclerosis should be carefully evaluated both at onset and during the follow-up for the possible coexistence of other autoimmune disorders. PubMed. Rheumatol Int. 2006 Sep 19. (Also see: MCTD) |
| Multiple sclerosis (MS) associated with systemic sclerosis (SSc). The report highlights the interesting association between MS and SSc that may be due to an overlapping pathogenetic mechanism for both processes. PubMed. Rheumatol Int. 2006 Dec 14. (Also see: Multiple Sclerosis) |
| Development of Additional Autoimmune Diseases in a Cohort of Patients with Systemic Sclerosis (SSc). It is likely that this association is multifactorial in genetically predisposed individuals. Physicians should remain alert to the possibility of the development of other autoimmune diseases in patients with SSc. F. Sivera. SAT0238 EULAR 2006. |
| Infections in systemic connective tissue diseases: systemic lupus erythematosus, scleroderma, and polymyositis/dermatomyositis. Patients who have these diseases, especially when receiving high doses of corticosteroids and immunosuppressive therapy, need to be monitored closely for these infections. PubMed. Infect Dis Clin North Am. 2006 Dec;20(4):849-75. (Also see: Scleroderma Treatments) |
| Anti PM-Scl antibodies. Study of prevalence and of meaning. Low prevalence and possible association with an overlap autoimmune syndrome of quite good prognosis are reported with anti PM-Scl antibodies. PubMed. Rev Med Interne. 2006 Jun 12. (Also see: What are Antibodies?) |
| Clinical Aspects of Systemic Sclerosis Overlap Syndromes. The association of systemic sclerosis (SSc) with other connective tissue diseases (dermato/polymyositis (DM/PM), rheumatoid arthritis (RA) et al) is poorly understood and is an actively discussed clinical problem. SSc-PM/DM and SSc-RA overlaps occur most often. O. V. Desinova. AB0191 EULAR 2005. (Also see: Dermatomyositis, and Rheumatoid Arthritis) |
| Sclerodermic linear lupus panniculitis: report of two cases. Lupus erythematosus panniculitis is a rare disease characterized by deep subcutaneous nodules, most commonly localized on the upper limbs and face. We present here the clinical characteristics, course and laboratory findings of 2 patients having linear lupus erythematosus panniculitis with localized scleroderma-like changes. PubMed. Dermatology. 2005;210(4):329-32. (Also see: Lupus and Linear Scleroderma) |
| A human T-cell lymphotropic virus type-1 (HTLV-1) carrier complicated with various autoimmune diseases including primary biliary cirrhosis. A 47-year-old woman diagnosed as having overlap syndrome with scleroderma, systemic lupus erythematosus and possible polymyositis associated with primary biliary cirrhosis. The tests suggest the possibility of a relationship between HTLV-1 infection and various autoimmune disorders including primary biliary cirrhosis. PubMed. Hepatol Res. 2005 Feb 7. (Also see: Liver Involvement, Lupus, and Polymyositis) |
| Severe Cardiac Involvement in Children with Systemic Sclerosis and Myositis Children with diffuse cutaneous SSc and features of polymyositis are prone to develop severe cardiomyopathy. Combination therapy of corticosteroids, MTX, and cyclosporine seems to be active on muscle, skin, and lung involvement but does not impair progression of esophageal or myocardial dysfunction. The Journal of Rheumatology VOLUME 29: NO. 8 AUGUST 2002. |
