| Systemic Sclerosis: Scleroderma in Overlap, MCTD, UCTD |
| This page was written by Shelley Ensz and has not yet been medically edited. See Disclaimer. |
| Shared Autoimmunity |
| Shared Autoimmunity is a rather loose term. It variously refers to autoantibodies, symptoms, or presence of autoimmune diseases within the same patient or within several or more members of the same family. |
| Overlap syndromes in the context of shared autoimmunity. "Shared autoimmunity" is the term being used for the presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheumatic diseases in one patient and the interplay of genetic and environmental factors leading to the presence of several autoimmune disease and/or their autoantibodies in families. PubMed. Autoimmunity. 2005 May;38(3):219-23. (Also see: Causes of Scleroderma: Genetics) |
| Are pediatric autoimmune diseases primarily genetic diseases? Advancing methods are leading to the discovery of genes associated with childhood autoimmune diseases. However, the genetic contribution to disease risk for any one gene remains less than 30% for most diseases, suggesting that pediatric autoimmunity is not primarily genetic in a classical sense. Shaw, E. A. Current Opinion in Rheumatology. September 2008. (Also see: Autoimmunity) |
| Immunogenetic mechanisms for the coexistence of organ-specific and systemic autoimmune diseases. Both types of autoimmune diseases may coexist in the same patient, either sequentially or concurrently, sustained by the presence of autoantibodies directed against the corresponding autoantigens. Journal of Autoimmune Diseases 2008, 5:1. |
| Development of Polymyalgia Rheumatica in Patients with Scleroderma. Systemic sclerosis (SSc) and polymyalgia rheumatica (PMR) are uncommon but not rare rheumatic diseases. The various musculoskeletal symptoms that accompany SSc can make the recognition of PMR challenging in these patients. J Rheumatol 2006 June;33:1206. Letters. (Also see: Renal Involvement) |
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