When a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called Undifferentiated Connective Tissue Disease (UCTD). (Also see Difficult Diagnosis)
Undifferentiated Connective Tissue Disease at risk for Systemic Sclerosis (SSc) (so far referred to as very early/early SSc or pre-SSc). This nosographic approach is instrumental to plan future studies devoted to investigate validated biomarkers heralding the development of major vascular disease manifestations as well as skin and/or organ fibrosis in patients at risk. PubMed, Autoimmun Rev, 11/18/2014.
Impaired endothelial function in patients with undifferentiated connective tissue disease (UCTD): a follow-up study. The data suggest that the presence of inflammation and autoantibodies provoke endothelial cell activation and/or injury in UCTD patients. PubMed, Rheumatology (Oxford), 2014 Jun 10.
The diagnosis and classification of undifferentiated connective tissue diseases (UCTD). Criteria for early phases of CTD may offer a valuable guide to the treating physician to set up appropriate follow up schedules as well as therapeutic protocols. PubMed, J Autoimmun, 2014 Feb 8.
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