Faulty Immune-priming Cells Start Autoimmunity. The failure of programming that sparks the death of dendritic cells, those that activate the immune system can initiate autoimmune disease. The problem begins with a process called programmed cell death or apoptosis. Mice bred to have a defect in apoptosis of their dendritic cells went on to develop autoimmune disease. Medical News Today 03-01-06.
Treatments and Dendritic Cells
An update on an immune system that goes awry in systemic sclerosis. We propose to approach SSc as a multistep immune-mediated disease that is in need of a therapeutic strategy designed to interfere with one or more aberrant molecular pathways. Targeting of dendritic cells could be such a target by which dampening the immune system could modify the course of SSc. van Bon L, Curr Opin Rheumatol. 2011 Aug 31.
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