[Skip to Content]
Home > Medical Directory > Scleroderma Symptoms > Causes of Scleroderma

Dendritic Cells

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Media Articles


Dendritic cells are involved in the regulation of the body's immune system response, and are thought to be a key to preventing or treating autoimmune diseases.(Also see: Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)
Faulty Immune-priming Cells Start Autoimmunity. The failure of programming that sparks the death of dendritic cells, those that activate the immune system can initiate autoimmune disease. The problem begins with a process called programmed cell death or apoptosis. Mice bred to have a defect in apoptosis of their dendritic cells went on to develop autoimmune disease. Medical News Today 03-01-06.

Treatments and Dendritic Cells

An update on an immune system that goes awry in systemic sclerosis. We propose to approach SSc as a multistep immune-mediated disease that is in need of a therapeutic strategy designed to interfere with one or more aberrant molecular pathways. Targeting of dendritic cells could be such a target by which dampening the immune system could modify the course of SSc. van Bon L, Curr Opin Rheumatol. 2011 Aug 31.

Dendritic Cells Research

Macrophages In The Spleen Regulate The Immune Response And Immune Tolerance. This is the first study demonstrating that macrophages in the marginal zone of the spleen regulate not only efficient clearance of dying cells, but also the selective engulfment of dying cells by dendritic cells. Science Daliy. 07/30/07. (Also see: Autoimmunity)

Media Articles

Queensland rheumatoid arthritis research offers hope for sufferers. A research team has been working on a new cell free therapy that will target the patient's own auto-immune system to kick in and treat the disease. PressZoom. 07/11/07. (Also see: Rheumatoid Arthritis)
Go to Causes of Scleroderma: Environmental

SCLERO.ORG is operated by the International Scleroderma Network, which is a full-service U.S. nonprofit 501(c)(3) established in 2002. We provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. Donate or Shop Now.

Questions? Post a message in Sclero Forums or email us directly at isn@sclero.org. Or call our Scleroderma Hotline (English only), Toll Free in U.S. 1-800-564-7099 or Direct at 1-952-831-3091. Ask for our Welcoming Email.

Our headquarters postal mailing address is: International Scleroderma Network (ISN), 7455 France Ave So #266, Edina, MN 55435-4702, United States.

The most important thing in the world to know about scleroderma...is sclero.org!
Home   Medical   News   Sclero Forums   Support   Translations  Donate or Shop
Copyright 1998-2015, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.