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| Dendritic Cells | ||||
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| Overview | ||||
| Dendritic cells are involved in the regulation of the body's immune system response, and are thought to be a key to preventing or treating autoimmune diseases. | ||||
| Faulty Immune-priming Cells Start Autoimmunity. The failure of programming that sparks the death of dendritic cells, those that activate the immune system can initiate autoimmune disease. The problem begins with a process called programmed cell death or apoptosis. Mice bred to have a defect in apoptosis of their dendritic cells went on to develop autoimmune disease. Medical News Today 03-01-06. | ||||
| Treatments and Dendritic Cells | ||||
| Dendritic cells as pharmacological targets for the generation of regulatory immunosuppressive effectors. New implications for allo-transplantation. Dendritic cells (DCs) play a central role in the establishment of tolerance/immunity, because they activate naive T cells (TCs). Therefore, the pharmacological modulation of DCs has become a major field of interest in immunology. There is now strong evidence that, DCs might be the key for antigen specific tolerance induction. PubMed. Curr Med Chem. 2005;12(16):1921-30. | ||||
| Immunotherapy via dendritic cells (DCs). Understanding DC heterogeneity and their role in immunopathology is critical to design better strategies for immunotherapy. PubMed. Adv Exp Med Biol. 2005;560:105-14. | ||||
| Dendritic Cells Research | ||||
| Macrophages In The Spleen Regulate The Immune Response And Immune Tolerance. This is the first study demonstrating that macrophages in the marginal zone of the spleen regulate not only efficient clearance of dying cells, but also the selective engulfment of dying cells by dendritic cells. Science Daliy. 07/30/07. (Also see: Autoimmunity) | ||||
| Complement receptor 3 sends a signal to dampen the immune system. Researchers reported that complement receptor 3 (CR3), a protein found on cell surfaces, inhibits dendritic cells, the sentinels of the immune system, from setting off an alarm signal that brings on a full immune response. News-Medical.Net 05/16/07. (Also see: Causes of Scleroderma: B and T Cells) | ||||
| Media Articles | ||||
| Queensland rheumatoid arthritis research offers hope for sufferers. A research team has been working on a new cell free therapy that will target the patient’s own auto-immune system to kick in and treat the disease. PressZoom. 07/11/07. (Also see: Rheumatoid Arthritis) |
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