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Vitamin D Deficiency, Sunshine, and Scleroderma

Overview
Autoimmune Diseases
Deficiencies of Vit D
Vit D and Scleroderma
Sunshine and Vit D
Supplementation

Overview

Vitamin D's major biological function is to maintain normal blood levels of calcium and phosphorus. Recent studies have demonstrated that individuals with low blood levels of vitamin D are at a higher risk of developing autoimmune diseases.
Vitamin D and autoimmunity. A review of the experimental, epidemiological and clinical studies illustrating the potential role of vitamin D in the development and perpetuation of autoimmune diseases. PubMed. Rev Med Interne. 2012 Feb;33(2):87-93.
The Biology Of Vitamin D: Classical And Non-Classical Actions. Innate and adaptive immunity may be profoundly affected in patients who are vitamin D insufficient, leading to increased risk of immune-related diseases. The aim of this presentation will be to describe the mechanisms that make up the vitamin D system and to provide an introduction to their integration with human immunity. M. Hewison. EULAR 2011 SP0203. Ann Rheum Dis 2011;70(Suppl3):54.
Dietary Supplement Fact Sheet: Vitamin D. Information about the popular supplement from Office of Dietary Supplements. National Institutes of Health. (Also see: Supplements)

Autoimmune Diseases and Vitamin D

Vitamin D supplementation, moderate sun exposure, and control of immune diseases. There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. Randomized controlled trials of vitamin D supplementation to treat these (and other) diseases have been disappointing. Discov Med. 2012 Jun;13(73):397-404.
The Effect Of Vitamin D On The Innate Immune Response In Arthritis. Vitamin D seems to act as one of the most important endogenous dowregulators of the innate immune response, at least in autoimmune rheumatic diseases. M. Cutolo. EULAR 2011 SP0204. Ann Rheum Dis 2011;70 (Suppl3):55.
25-Hydroxyvitamin D Levels and Vitamin D Deficiency in Children with Rheumatologic Disorders and Controls. Twenty percent of patients attending a pediatric rheumatology clinic were vitamin D deficient. Patients with autoimmune disorders were more likely to be vitamin D deficient than patients with nonautoimmune conditions. Screening of serum 25(OH)D levels should be performed for patients with autoimmune disorders. Christina F. Pelajo. Journal of Rheumatology. July 15, 2011. (Also see: Rheumatic Disease)
Assessment Of Bone Density (BMD) In Women With Systemic Scleroderma (SSc) and Its Relationships With Disease Parameters And Vitamin D Status. Decreased BMD seems to be associated with prolonged disease duration, severe joint involvement, malabsorption syndrome and immunological status. Also, SSc patients had very low levels of 25-hydroxyvitamin D3 than controls. Y. Ibn Yacoub. EULAR 2011 SAT0451. Ann Rheum Dis 2011;70(Suppl3):669. (Also see: Bone Density)
Vitamin D Levels And Bone Loss In Systemic Sclerosis (SSc). The lower BMD (bone density) values in SSc patients and the vitamin D deficiency/insufficiency reported in our study may be linked to multiple risk factors, such as insufficient sun exposure due to disability, or disease severity B. Seriolo. EULAR FRI0397. Ann Rheum Dis 2011;70(Suppl3):477. (Also see: Bone Density)

Deficiencies of Vitamin D

Vitamin D and Calcium Supplements May Not Prevent Fractures. For most people, the evidence doesn't support any bone benefit of the popular supplements. Time Healthland 02/26/2013. (Also see: Scleroderma Supplement Guide: Calcium)
Vitamin D Supplementation: What's Known, What to Do, and What's Needed. In patients with documented vitamin D deficiency, a cumulative dose of at least 600,000 IU administered over several weeks appears to be necessary to replenish vitamin D stores. Single large doses of 300,000-500,000 IU should be avoided. Pharmacotherapy. 2012 Apr;32(4):354-82.
Vitamin D Status And Chronic Musculoskeletal Pain (CMP) In Older Adults: Is There A Link? The results of the present study demonstrate that patients with CMP have lower levels of vitamin D compared to individuals who are pain-free. S. Abou-Raya. EULAR 2011 OP0258. Ann Rheum Dis 2011;70(Suppl3):156.
Study shows vitamin D deficiencies may impact onset of autoimmune lung disease. Researchers evaluated 118 patients. Overall, those with connective tissue disease-related Interstitial Lung Disease (ILD) were more likely to have vitamin D deficiency—52 percent versus 20 percent—and insufficiency—79 percent versus 31 percent—than other forms of ILD. Katie Pence, UCAHC. EurekAlert! 01/04/2011. (Also see: Pulmonary Fibrosis)

Vitamin D Deficiency and Scleroderma

Serum 25-OH Vitamin D Concentrations Are Linked With Various Clinical Aspects In Patients With Systemic Sclerosis (SSc). Patients with SSc have significantly lower serum vitamin D concentrations compared to healthy controls; moreover fibrosis of the cutaneous tissue is inversely related to the vitamin D concentration. H. Amital. EULAR 2011 FRI0412. Ann Rheum Dis 2011;70(Suppl3):482.

Sunshine Exposure and Protection

Safe Sun Protection. For people with specific autoimmune disorders, protection from the sun should be a serious perennial consideration. Conditions such as Lupus, dermatomyositis, scleroderma and vitaligo are autoimmune diseases that are sun-sensitive. Arthritis Today.

Sunshine and Vitamin D

Scientists claim artificial sunshine may be key to treating Multiple Sclerosis (MS). The study shows that UV-B light, which mimics sunshine, can have a striking effect on the immune system of patients. Scotland News. 07/17/12. (Also see: Multiple Sclerosis)

Supplementation of Vitamin D

Before taking supplements of any kind, consult with your physicians.
Study: Vitamin D Supplements Don’t Protect Against Fractures. Keeping bones strong may take more than popping a few pills, according to the latest research. Times Healtland, 10/10/2013.
Vitamin D warning: Too much can harm your heart. Scientists have long known that low levels of the nutrient can hurt the heart, but new research shows that higher than normal levels can make it beat too fast and out of rhythm, a condition called atrial fibrillation. MSNBC. 11/18/2011. (Also see: Heart Involvement, Scleroderma Supplement Guide)
 
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